(1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-4-guanidino-butyl)-phosphonic acid dimethyl ester; hydrochloride

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Chemical Name:(1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-4-guanidino-butyl)-phosphonic acid dimethyl ester; hydrochloride
CAS No.:146548-72-3
Molecular Formula:C₂₃H₃₇N₆O₆P*ClH
Molecular Weight:561.018
Hs Code.:

(1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-4-guanidino-butyl)-phosphonic acid dimethyl ester; hydrochloride

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Chemical Property of (1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-4-guanidino-butyl)-phosphonic acid dimethyl ester; hydrochloride

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Technology Process of (1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-4-guanidino-butyl)-phosphonic acid dimethyl ester; hydrochloride

There total 3 articles about (1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-4-guanidino-butyl)-phosphonic acid dimethyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1184-90-3
aminoiminomethanesulfonic acid

: (1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-4-amino-butyl)-phosphonic acid dimethyl ester; hydrochloride

: 146548-72-3,146610-38-0
(1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-4-guanidino-butyl)-phosphonic acid dimethyl ester; hydrochloride

Guidance literature:: With hydrogenchloride; dmap; In ethanol; at 80 ℃;
DOI:10.1016/0040-4039(93)88011-7

Reference yield:

: 146548-68-7
[1-Amino-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-phosphonic acid dimethyl ester

: 146548-72-3,146610-38-0
(1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-4-guanidino-butyl)-phosphonic acid dimethyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: i-BuOC(=O)Cl, 4-methylmorpholine, Et₃N / tetrahydrofuran / Ambient temperature

2: 1) H₂NNH₂*H₂O, 2) 10percent HCl / methanol / Ambient temperature

3: 1) DMAP, 2) 10percent HCl / ethanol / 80 °C

With 4-methyl-morpholine; hydrogenchloride; dmap; hydrazine hydrate; triethylamine; isobutyl chloroformate; In tetrahydrofuran; methanol; ethanol;
DOI:10.1016/0040-4039(93)88011-7

Reference yield:

: [1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-phosphonic acid dimethyl ester

: 146548-72-3,146610-38-0
(1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-4-guanidino-butyl)-phosphonic acid dimethyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 1) H₂NNH₂*H₂O, 2) 10percent HCl / methanol / Ambient temperature

2: 1) DMAP, 2) 10percent HCl / ethanol / 80 °C

With hydrogenchloride; dmap; hydrazine hydrate; In methanol; ethanol;
DOI:10.1016/0040-4039(93)88011-7