Ethyl 4-(2-aminophenoxy)butanoate

Base Information

• Chemical Name: Ethyl 4-(2-aminophenoxy)butanoate
• CAS No.: 112290-16-1
• Molecular Formula: C12H17NO3
• Molecular Weight: 223.272
• DSSTox Substance ID: DTXSID60473554
• Nikkaji Number: J1.272.510H
• Wikidata: Q82303034
• Mol file: 112290-16-1.mol

Synonyms:Ethyl 4-(2-aminophenoxy)butanoate;112290-16-1;Butanoic acid, 4-(2-aminophenoxy)-, ethyl ester;ethyl 4-(2-aminophenoxy)butyrate;SCHEMBL2987183;DTXSID60473554;JOMNALFFMABHGF-UHFFFAOYSA-N;FT-0750504;A1-25830

Chemical Property of Ethyl 4-(2-aminophenoxy)butanoate

Chemical Property:

• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 7
• Exact Mass: 223.12084340
• Heavy Atom Count: 16
• Complexity: 208

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)CCCOC1=CC=CC=C1N

Technology Process of Ethyl 4-(2-aminophenoxy)butanoate

There total 5 articles about Ethyl 4-(2-aminophenoxy)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(2-nitrophenoxy)butanoic acid ethyl ester (112290-15-0) → 4-(2-aminophenoxy)-butanoic acid ethyl ester (112290-16-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; under 2068.6 Torr; Ambient temperature;

DOI:10.1006/bioo.1996.0033

Reference yield:

paradium-carbon + 4-(2-nitrophenoxy)butanoic acid ethyl ester (112290-15-0) → 4-(2-aminophenoxy)-butanoic acid ethyl ester (112290-16-1)

Guidance literature:

With sodium chloride; sodium hydrogencarbonate; In ethanol; chloroform;

Reference yield:

2-hydroxynitrobenzene (88-75-5,78813-12-4) → 4-(2-aminophenoxy)-butanoic acid ethyl ester (112290-16-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / K₂CO₃ / acetone / Heating

2: 1.0 g / H₂ / 5percent Pd/C / ethyl acetate / 2068.6 Torr / Ambient temperature

With hydrogen; potassium carbonate; palladium on activated charcoal; In ethyl acetate; acetone;

DOI:10.1006/bioo.1996.0033

upstream raw materials:

4-(2-nitrophenoxy)butanoic acid ethyl ester

Ethyl 4-bromobutyrate

2-hydroxynitrobenzene

Downstream raw materials:

4-{2-[(E)-3-(1-sec-Butyl-1H-indol-5-yl)-but-2-enoylamino]-phenoxy}-butyric acid ethyl ester

4-{2-[(E)-3-(1-Benzyl-1H-indol-5-yl)-but-2-enoylamino]-phenoxy}-butyric acid ethyl ester

4-{2-[(E)-3-(1-Pentyl-1H-indol-5-yl)-but-2-enoylamino]-phenoxy}-butyric acid ethyl ester

4-(2-{(E)-3-[1-(1-Methyl-butyl)-1H-indol-5-yl]-but-2-enoylamino}-phenoxy)-butyric acid ethyl ester