((1R,2S,4aR,8aR)-2-Benzyloxy-5,5,8a-trimethyl-decahydro-naphthalen-1-yl)-methanol

Base Information

Chemical Name:((1R,2S,4aR,8aR)-2-Benzyloxy-5,5,8a-trimethyl-decahydro-naphthalen-1-yl)-methanol
CAS No.:211053-87-1
Molecular Formula:C₂₁H₃₂O₂
Molecular Weight:316.484
Hs Code.:

Synonyms:

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Chemical Property of ((1R,2S,4aR,8aR)-2-Benzyloxy-5,5,8a-trimethyl-decahydro-naphthalen-1-yl)-methanol

Chemical Property:

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Technology Process of ((1R,2S,4aR,8aR)-2-Benzyloxy-5,5,8a-trimethyl-decahydro-naphthalen-1-yl)-methanol

There total 7 articles about ((1R,2S,4aR,8aR)-2-Benzyloxy-5,5,8a-trimethyl-decahydro-naphthalen-1-yl)-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 59633-91-9,65754-93-0,108944-87-2,108944-88-3,136982-34-8,146611-16-7,807360-95-8
rac-12-nor-drimane-8α,11-diol

: 211053-87-1
((1R,2S,4aR,8aR)-2-Benzyloxy-5,5,8a-trimethyl-decahydro-naphthalen-1-yl)-methanol

Guidance literature:: Multi-step reaction with 6 steps

1: 99 percent / conc. H₂SO₄ / dimethylsulfoxide / 1 h / Ambient temperature

2: 99 percent / p-dimethylaminopyridine, pyridine / 1 h / Ambient temperature

3: acylase I (Aspergillus melleus) / diisopropyl ether; H₂O / 48 h / 33 °C

4: 92 percent / H₂ / 20percent Pd(OH)2-C / methanol / Ambient temperature

5: conc. H₂SO₄ / dimethylsulfoxide / 0.5 h / Ambient temperature

6: LiAlH₄, AlCl₃ / diethyl ether / 0.5 h / -20 °C

With pyridine; dmap; lithium aluminium tetrahydride; aluminium trichloride; acylase I (Aspergillus melleus); sulfuric acid; hydrogen; palladium hydroxide - carbon; In methanol; diethyl ether; di-isopropyl ether; water; dimethyl sulfoxide;
DOI:10.1016/S0957-4166(98)00172-4

Reference yield:

: 1-((3R,4aS,6aR,10aR,10bR)-7,7,10a-Trimethyl-decahydro-naphtho[2,1-d][1,3]dioxin-3-yl)-naphthalen-2-ol

: 211053-87-1
((1R,2S,4aR,8aR)-2-Benzyloxy-5,5,8a-trimethyl-decahydro-naphthalen-1-yl)-methanol

Guidance literature:: Multi-step reaction with 5 steps

1: 99 percent / p-dimethylaminopyridine, pyridine / 1 h / Ambient temperature

2: acylase I (Aspergillus melleus) / diisopropyl ether; H₂O / 48 h / 33 °C

3: 92 percent / H₂ / 20percent Pd(OH)2-C / methanol / Ambient temperature

4: conc. H₂SO₄ / dimethylsulfoxide / 0.5 h / Ambient temperature

5: LiAlH₄, AlCl₃ / diethyl ether / 0.5 h / -20 °C

With pyridine; dmap; lithium aluminium tetrahydride; aluminium trichloride; acylase I (Aspergillus melleus); sulfuric acid; hydrogen; palladium hydroxide - carbon; In methanol; diethyl ether; di-isopropyl ether; water; dimethyl sulfoxide;
DOI:10.1016/S0957-4166(98)00172-4

Reference yield:

: 8-((3R,4aS,6aR,10aR,10bR)-7,7,10a-Trimethyl-decahydro-naphtho[2,1-d][1,3]dioxin-3-yl)-naphthalen-1-ol

: 211053-87-1
((1R,2S,4aR,8aR)-2-Benzyloxy-5,5,8a-trimethyl-decahydro-naphthalen-1-yl)-methanol

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / H₂ / 20percent Pd(OH)2-C / methanol / Ambient temperature

2: conc. H₂SO₄ / dimethylsulfoxide / 0.5 h / Ambient temperature

3: LiAlH₄, AlCl₃ / diethyl ether / 0.5 h / -20 °C

With lithium aluminium tetrahydride; aluminium trichloride; sulfuric acid; hydrogen; palladium hydroxide - carbon; In methanol; diethyl ether; dimethyl sulfoxide;
DOI:10.1016/S0957-4166(98)00172-4