N-<4-amino>ethyl>amino>benzoyl>-L-glutamic acid 5'-monophosphate

Base Information

Chemical Name:N-<4-amino>ethyl>amino>benzoyl>-L-glutamic acid 5'-monophosphate
CAS No.:107716-41-6
Molecular Formula:C₂₉H₃₇N₈O₁₄P
Molecular Weight:752.632
Hs Code.:

N-<4-<N-<2-<N-(2-amino-4-oxo-6-methylpyrimidin-5-yl)-N-<(2'-deoxyuridin-5-yl)methyl>amino>ethyl>amino>benzoyl>-L-glutamic acid 5'-monophosphate

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Chemical Property of N-<4-amino>ethyl>amino>benzoyl>-L-glutamic acid 5'-monophosphate

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Technology Process of N-<4-amino>ethyl>amino>benzoyl>-L-glutamic acid 5'-monophosphate

There total 6 articles about N-<4-amino>ethyl>amino>benzoyl>-L-glutamic acid 5'-monophosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13726-52-8
diethyl N-(p-aminobenzoyl)-L-glutamate

: 107716-41-6
N-<4-amino>ethyl>amino>benzoyl>-L-glutamic acid 5'-monophosphate

Guidance literature:: Multi-step reaction with 6 steps

1: 40 percent / aq. acetic acid / 1.) 0 deg C, 2.) room temperature, 17 h

2: 6.50 g / pyridine / 1 h / Ambient temperature

3: 18 percent / dimethylformamide / 48 h / 85 - 90 °C

4: 67 percent / HBr, phenol / acetic acid / 3.5 h

5: 41 percent / NaHCO₃ / dimethylformamide / 2 h / Ambient temperature

6: 1.) Zn, Cu, acetylacetone, 2.) NaOH / 1.) DMF, 50 deg C to 55 deg C, 1.5 h, 2.) ethanol, 48 h

With sodium hydroxide; hydrogen bromide; copper; sodium hydrogencarbonate; acetylacetone; zinc; phenol; In pyridine; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00119a012

Reference yield:

: 107716-29-0
diethyl N-<4-benzoyl>-L-glutamate

: 107716-41-6
N-<4-amino>ethyl>amino>benzoyl>-L-glutamic acid 5'-monophosphate

Guidance literature:: Multi-step reaction with 5 steps

1: 6.50 g / pyridine / 1 h / Ambient temperature

2: 18 percent / dimethylformamide / 48 h / 85 - 90 °C

3: 67 percent / HBr, phenol / acetic acid / 3.5 h

4: 41 percent / NaHCO₃ / dimethylformamide / 2 h / Ambient temperature

5: 1.) Zn, Cu, acetylacetone, 2.) NaOH / 1.) DMF, 50 deg C to 55 deg C, 1.5 h, 2.) ethanol, 48 h

With sodium hydroxide; hydrogen bromide; copper; sodium hydrogencarbonate; acetylacetone; zinc; phenol; In pyridine; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00119a012

Reference yield:

: 107716-33-6
(S)-2-{4-[2-(2-Amino-4-methyl-6-oxo-1,6-dihydro-pyrimidin-5-ylamino)-ethylamino]-benzoylamino}-pentanedioic acid diethyl ester

: 107716-41-6
N-<4-amino>ethyl>amino>benzoyl>-L-glutamic acid 5'-monophosphate

Guidance literature:: Multi-step reaction with 2 steps

1: 41 percent / NaHCO₃ / dimethylformamide / 2 h / Ambient temperature

2: 1.) Zn, Cu, acetylacetone, 2.) NaOH / 1.) DMF, 50 deg C to 55 deg C, 1.5 h, 2.) ethanol, 48 h

With sodium hydroxide; copper; sodium hydrogencarbonate; acetylacetone; zinc; In N,N-dimethyl-formamide;
DOI:10.1021/jm00119a012