(1S,2S)-1-(p-tert-butylphenylthio)-2-cyclohexane

Base Information

• Chemical Name: (1S,2S)-1-(p-tert-butylphenylthio)-2-cyclohexane
• CAS No.: 161260-04-4
• Molecular Formula: C₂₃H₂₈N₂O₃S
• Molecular Weight: 412.553
• Mol file: 161260-04-4.mol

Synonyms:

Chemical Property of (1S,2S)-1-(p-tert-butylphenylthio)-2-cyclohexane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2S)-1-(p-tert-butylphenylthio)-2-cyclohexane

There total 1 articles about (1S,2S)-1-(p-tert-butylphenylthio)-2-cyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-t-butylbenzenethiol (2396-68-1) + 7-(4-nitrobenzoyl)-7-azabicyclo<4.1.0>heptane → (1R,2R)-2-(p-tert-butylbenzenethio)-cyclohexane + (1S,2S)-1-(p-tert-butylphenylthio)-2-cyclohexane (161260-04-4)

Guidance literature:

L-(+)-diisopropyl tartrate; zinc(II) chloride; In dichloromethane; at 0 ℃; for 14h; Product distribution; var. ratio of reactants, amount of catalyst;

DOI:10.1039/c39940002699

Reference yield:

(1S,2S)-1-(p-tert-butylphenylthio)-2-cyclohexane (161260-04-4) → trans-2-(p-tert-butylbenzenethio)cyclohexylamine

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1039/c39940002699

Reference yield:

(1S,2S)-1-(p-tert-butylphenylthio)-2-cyclohexane (161260-04-4) → trans-2-(p-tert-butylbenzenethio)cyclohexanol (161344-81-6)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄ / tetrahydrofuran / 18 h / Heating

2: NaNO₂, AcOH

With lithium aluminium tetrahydride; acetic acid; sodium nitrite; In tetrahydrofuran;

DOI:10.1016/0040-4020(96)00370-5

upstream raw materials:

4-t-butylbenzenethiol

Downstream raw materials:

trans-2-(p-tert-butylbenzenethio)cyclohexanol