Technology Process of 2-[(benzyloxy)methyl]-1,1-dimethyl-5,8-dioxaspiro[3.4]octane
There total 1 articles about 2-[(benzyloxy)methyl]-1,1-dimethyl-5,8-dioxaspiro[3.4]octane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 2,4,6-trimethyl-pyridine; trifluoromethylsulfonic anhydride / 1,2-dichloro-ethane / 19 h / Reflux; Inert atmosphere
2: toluene-4-sulfonic acid / benzene / 2.5 h / Reflux; Inert atmosphere
With
2,4,6-trimethyl-pyridine; trifluoromethylsulfonic anhydride; toluene-4-sulfonic acid;
In
1,2-dichloro-ethane; benzene;
DOI:10.1016/j.tetlet.2011.11.067
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 20 % Pd(OH)2/C; hydrogen / ethanol / 1.5 h / 20 °C
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.25 h / -78 °C / Inert atmosphere
2.2: -78 - 20 °C / Inert atmosphere
3.1: potassium carbonate / methanol / 24 h / Inert atmosphere
4.1: hydrogenchloride / water / 8 h / Inert atmosphere; Reflux
5.1: dicobalt octacarbonyl / dichloromethane / 3 h / 20 °C / Inert atmosphere
5.2: 4 h / 20 °C / Inert atmosphere
5.3: 1 h / 0 °C / Inert atmosphere
With
hydrogenchloride; dicobalt octacarbonyl; oxalyl dichloride; 20 % Pd(OH)2/C; hydrogen; potassium carbonate; dimethyl sulfoxide;
In
methanol; ethanol; dichloromethane; water;
2.1: Swern oxidation / 2.2: Swern oxidation;
DOI:10.1016/j.tetlet.2011.11.067
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 20 % Pd(OH)2/C; hydrogen / ethanol / 1.5 h / 20 °C
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.25 h / -78 °C / Inert atmosphere
2.2: -78 - 20 °C / Inert atmosphere
3.1: potassium carbonate / methanol / 24 h / Inert atmosphere
With
oxalyl dichloride; 20 % Pd(OH)2/C; hydrogen; potassium carbonate; dimethyl sulfoxide;
In
methanol; ethanol; dichloromethane;
2.1: Swern oxidation / 2.2: Swern oxidation;
DOI:10.1016/j.tetlet.2011.11.067
