Technology Process of Toluene-4-sulfonic acid 4-((2S,4S,5R)-4-methoxymethoxy-5-trityloxymethyl-tetrahydro-furan-2-yl)-butyl ester
There total 9 articles about Toluene-4-sulfonic acid 4-((2S,4S,5R)-4-methoxymethoxy-5-trityloxymethyl-tetrahydro-furan-2-yl)-butyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: DMAP; pyridine
2: t-BuOK / tetrahydrofuran
3: i-Pr2NEt
4: DIBAL / CH2Cl2
5: NaH / tetrahydrofuran
6: H2 / Pd/C / ethanol
7: LAH / tetrahydrofuran
8: pyridine
With
pyridine; dmap; lithium aluminium tetrahydride; potassium tert-butylate; hydrogen; sodium hydride; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dichloromethane;
2: Wittig-Honor-Emmons reaction;
DOI:10.1016/S0960-894X(00)00666-1
- Guidance literature:
-
Multi-step reaction with 7 steps
1: t-BuOK / tetrahydrofuran
2: i-Pr2NEt
3: DIBAL / CH2Cl2
4: NaH / tetrahydrofuran
5: H2 / Pd/C / ethanol
6: LAH / tetrahydrofuran
7: pyridine
With
pyridine; lithium aluminium tetrahydride; potassium tert-butylate; hydrogen; sodium hydride; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dichloromethane;
1: Wittig-Honor-Emmons reaction;
DOI:10.1016/S0960-894X(00)00666-1
- Guidance literature:
-
Multi-step reaction with 8 steps
1: DMAP; pyridine
2: t-BuOK / tetrahydrofuran
3: i-Pr2NEt
4: DIBAL / CH2Cl2
5: NaH / tetrahydrofuran
6: H2 / Pd/C / ethanol
7: LAH / tetrahydrofuran
8: pyridine
With
pyridine; dmap; lithium aluminium tetrahydride; potassium tert-butylate; hydrogen; sodium hydride; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dichloromethane;
2: Wittig-Honor-Emmons reaction;
DOI:10.1016/S0960-894X(00)00666-1