(S)-2-{(S)-4-Benzyloxycarbonyl-2-[2-(2-{(S)-2-[((S)-1-benzyloxycarbonyl-pyrrolidine-2-carbonyl)-amino]-3-methyl-butyrylamino}-2-methyl-propionylamino)-2-methyl-propionylamino]-butyrylamino}-pentanedioic acid 5-benzyl ester 1-tert-butyl ester

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Chemical Name:(S)-2-{(S)-4-Benzyloxycarbonyl-2-[2-(2-{(S)-2-[((S)-1-benzyloxycarbonyl-pyrrolidine-2-carbonyl)-amino]-3-methyl-butyrylamino}-2-methyl-propionylamino)-2-methyl-propionylamino]-butyrylamino}-pentanedioic acid 5-benzyl ester 1-tert-butyl ester
CAS No.:105608-12-6
Molecular Formula:C₅₄H₇₂N₆O₁₃
Molecular Weight:1013.2
Hs Code.:

(S)-2-{(S)-4-Benzyloxycarbonyl-2-[2-(2-{(S)-2-[((S)-1-benzyloxycarbonyl-pyrrolidine-2-carbonyl)-amino]-3-methyl-butyrylamino}-2-methyl-propionylamino)-2-methyl-propionylamino]-butyrylamino}-pentanedioic acid 5-benzyl ester 1-tert-butyl ester

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Chemical Property of (S)-2-{(S)-4-Benzyloxycarbonyl-2-[2-(2-{(S)-2-[((S)-1-benzyloxycarbonyl-pyrrolidine-2-carbonyl)-amino]-3-methyl-butyrylamino}-2-methyl-propionylamino)-2-methyl-propionylamino]-butyrylamino}-pentanedioic acid 5-benzyl ester 1-tert-butyl ester

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Technology Process of (S)-2-{(S)-4-Benzyloxycarbonyl-2-[2-(2-{(S)-2-[((S)-1-benzyloxycarbonyl-pyrrolidine-2-carbonyl)-amino]-3-methyl-butyrylamino}-2-methyl-propionylamino)-2-methyl-propionylamino]-butyrylamino}-pentanedioic acid 5-benzyl ester 1-tert-butyl ester

There total 5 articles about (S)-2-{(S)-4-Benzyloxycarbonyl-2-[2-(2-{(S)-2-[((S)-1-benzyloxycarbonyl-pyrrolidine-2-carbonyl)-amino]-3-methyl-butyrylamino}-2-methyl-propionylamino)-2-methyl-propionylamino]-butyrylamino}-pentanedioic acid 5-benzyl ester 1-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1676-73-9,25014-27-1
L-glutamic acid γ-benzyl ester

: 105608-12-6
(S)-2-{(S)-4-Benzyloxycarbonyl-2-[2-(2-{(S)-2-[((S)-1-benzyloxycarbonyl-pyrrolidine-2-carbonyl)-amino]-3-methyl-butyrylamino}-2-methyl-propionylamino)-2-methyl-propionylamino]-butyrylamino}-pentanedioic acid 5-benzyl ester 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) cc. H₂SO₄; 2.) HCl / 1.) dioxane, 20 deg C, 4 d; 2.) ether, -10 deg C

2: 1.) triethylamine; 2.) 1-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) / 1.) PhMe, 20 deg C, 15 min; 2.) PhMe, 50 deg C, 72 h

3: trifluoroacetic acid / CDCl₃ / 1.5 h

4: 2.) 1-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) / 2.) PhMe, RT, 72 h

With hydrogenchloride; sulfuric acid; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; trifluoroacetic acid; In chloroform-d1;

Reference yield:

: 71890-87-4
N-phenylmethoxycarbonyl-L-prolyl-L-valyl-2-methylalanyl-2-methylalanine

: 105608-12-6
(S)-2-{(S)-4-Benzyloxycarbonyl-2-[2-(2-{(S)-2-[((S)-1-benzyloxycarbonyl-pyrrolidine-2-carbonyl)-amino]-3-methyl-butyrylamino}-2-methyl-propionylamino)-2-methyl-propionylamino]-butyrylamino}-pentanedioic acid 5-benzyl ester 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) triethylamine; 2.) 1-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) / 1.) PhMe, 20 deg C, 15 min; 2.) PhMe, 50 deg C, 72 h

2: trifluoroacetic acid / CDCl₃ / 1.5 h

3: 2.) 1-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) / 2.) PhMe, RT, 72 h

With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; trifluoroacetic acid; In chloroform-d1;

Reference yield:

: 105590-97-4
L-glutamic acid γ-benzyl α-tert-butyl ester hydrochloride

: 105608-12-6
(S)-2-{(S)-4-Benzyloxycarbonyl-2-[2-(2-{(S)-2-[((S)-1-benzyloxycarbonyl-pyrrolidine-2-carbonyl)-amino]-3-methyl-butyrylamino}-2-methyl-propionylamino)-2-methyl-propionylamino]-butyrylamino}-pentanedioic acid 5-benzyl ester 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) triethylamine; 2.) 1-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) / 1.) PhMe, 20 deg C, 15 min; 2.) PhMe, 50 deg C, 72 h

2: trifluoroacetic acid / CDCl₃ / 1.5 h

3: 2.) 1-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) / 2.) PhMe, RT, 72 h

With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; trifluoroacetic acid; In chloroform-d1;