Technology Process of 1-(5-(cyclohexylmethyl)-3-((2-ethylpyridin-3-yl)oxy)pyridin-2-yl)-3-methylurea
There total 12 articles about 1-(5-(cyclohexylmethyl)-3-((2-ethylpyridin-3-yl)oxy)pyridin-2-yl)-3-methylurea which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 10 °C
1.2: 0.5 h / 10 °C
2.1: sulfuric acid / 20 °C
3.1: N-Bromosuccinimide; potassium hydroxide / methanol; water / 0 - 100 °C
4.1: pyridine / dichloromethane / 0 - 20 °C
5.1: triethylamine / dichloromethane; tetrahydrofuran
6.1: palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / tetrahydrofuran / Inert atmosphere; Reflux
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; pyridine; N-Bromosuccinimide; sulfuric acid; palladium diacetate; sodium hydride; triethylamine; potassium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ml500341w
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sulfuric acid / 20 °C
2: N-Bromosuccinimide; potassium hydroxide / methanol; water / 0 - 100 °C
3: pyridine / dichloromethane / 0 - 20 °C
4: triethylamine / dichloromethane; tetrahydrofuran
5: palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / tetrahydrofuran / Inert atmosphere; Reflux
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; pyridine; N-Bromosuccinimide; sulfuric acid; palladium diacetate; triethylamine; potassium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/ml500341w
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 10 °C
1.2: 0.5 h / 10 °C
2.1: sulfuric acid / 20 °C
3.1: N-Bromosuccinimide; potassium hydroxide / methanol; water / 0 - 100 °C
4.1: pyridine / dichloromethane / 0 - 20 °C
5.1: triethylamine / dichloromethane; tetrahydrofuran
6.1: palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / tetrahydrofuran / Inert atmosphere; Reflux
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; pyridine; N-Bromosuccinimide; sulfuric acid; palladium diacetate; sodium hydride; triethylamine; potassium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ml500341w
