4-Nitro-benzoic acid (R)-1-[(2S,7R)-7-((R)-2-acetoxy-1-methanesulfonyloxy-ethyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-propyl ester

Base Information

• Chemical Name: 4-Nitro-benzoic acid (R)-1-[(2S,7R)-7-((R)-2-acetoxy-1-methanesulfonyloxy-ethyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-propyl ester
• CAS No.: 326853-52-5
• Molecular Formula: C₂₁H₂₇NO₁₀S
• Molecular Weight: 485.512

Synonyms:

Chemical Property of 4-Nitro-benzoic acid (R)-1-[(2S,7R)-7-((R)-2-acetoxy-1-methanesulfonyloxy-ethyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Nitro-benzoic acid (R)-1-[(2S,7R)-7-((R)-2-acetoxy-1-methanesulfonyloxy-ethyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-propyl ester

There total 16 articles about 4-Nitro-benzoic acid (R)-1-[(2S,7R)-7-((R)-2-acetoxy-1-methanesulfonyloxy-ethyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4S,5S)-4-ethyl-5-hydroxymethyl-1,3-dioxolane (64273-32-1) → 4-Nitro-benzoic acid (R)-1-[(2S,7R)-7-((R)-2-acetoxy-1-methanesulfonyloxy-ethyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-propyl ester (326853-52-5)

Guidance literature:

Multi-step reaction with 16 steps

1.1: DMAP; TEA / CH₂Cl₂

2.1: Amberlyst 15 / methanol

3.1: 94 percent / K₂CO₃ / methanol; CH₂Cl₂

4.1: 89 percent / i-Pr₂NEt; DMAP / 1,2-dichloro-ethane / 50 °C

5.1: 91 percent / dimethylsulfoxide / 0 °C

6.1: 79 percent / NaH / tetrahydrofuran

7.1: 76 percent / n-BuLi; BF₃*OEt₂ / tetrahydrofuran / -78 °C

8.1: 99 percent / DMAP; Pyridine / CH₂Cl₂

9.1: 85 percent / TBAF / tetrahydrofuran

10.1: 99 percent / H₂ / Lindlar catalyst / methanol

11.1: (Bu₃Sn)2O / toluene / Heating

11.2: 97 percent / Zn(OTf)2 / 90 °C

12.1: 99 percent / TEA; DMAP / CH₂Cl₂

13.1: 81 percent / ZnBr₂ / 1,2-dichloro-ethane

14.1: 82 percent / DEAD; Ph₃P / tetrahydrofuran

15.1: PhSTMS; ZnI₂; Bu₄I / CH₂Cl₂

15.2: TBAF / tetrahydrofuran

15.3: silica gel / CH₂Cl₂

16.1: TEA; DMAP / CH₂Cl₂

With pyridine; dmap; n-butyllithium; Amberlyst 15; phenylthiotrimethylsilane; TEA; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; bis(tri-n-butyltin)oxide; zinc(II) iodide; zinc dibromide; diethylazodicarboxylate; Lindlar's catalyst; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane; toluene; 7.1: Yamaguchi reaction / 14.1: Mitsunobu reaction / 15.1: Nicolaou reaction;

DOI:10.1016/S0040-4039(00)01880-3

Reference yield:

(4S,5S)-(-)-5-Ethyl-2,2-dimethyl-4-(tosyloxymethyl)-1,3-dioxolan (64308-75-4) → 4-Nitro-benzoic acid (R)-1-[(2S,7R)-7-((R)-2-acetoxy-1-methanesulfonyloxy-ethyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-propyl ester (326853-52-5)

Guidance literature:

Multi-step reaction with 15 steps

1.1: Amberlyst 15 / methanol

2.1: 94 percent / K₂CO₃ / methanol; CH₂Cl₂

3.1: 89 percent / i-Pr₂NEt; DMAP / 1,2-dichloro-ethane / 50 °C

4.1: 91 percent / dimethylsulfoxide / 0 °C

5.1: 79 percent / NaH / tetrahydrofuran

6.1: 76 percent / n-BuLi; BF₃*OEt₂ / tetrahydrofuran / -78 °C

7.1: 99 percent / DMAP; Pyridine / CH₂Cl₂

8.1: 85 percent / TBAF / tetrahydrofuran

9.1: 99 percent / H₂ / Lindlar catalyst / methanol

10.1: (Bu₃Sn)2O / toluene / Heating

10.2: 97 percent / Zn(OTf)2 / 90 °C

11.1: 99 percent / TEA; DMAP / CH₂Cl₂

12.1: 81 percent / ZnBr₂ / 1,2-dichloro-ethane

13.1: 82 percent / DEAD; Ph₃P / tetrahydrofuran

14.1: PhSTMS; ZnI₂; Bu₄I / CH₂Cl₂

14.2: TBAF / tetrahydrofuran

14.3: silica gel / CH₂Cl₂

15.1: TEA; DMAP / CH₂Cl₂

With pyridine; dmap; n-butyllithium; Amberlyst 15; phenylthiotrimethylsilane; TEA; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; bis(tri-n-butyltin)oxide; zinc(II) iodide; zinc dibromide; diethylazodicarboxylate; Lindlar's catalyst; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane; toluene; 6.1: Yamaguchi reaction / 13.1: Mitsunobu reaction / 14.1: Nicolaou reaction;

DOI:10.1016/S0040-4039(00)01880-3

Reference yield:

(2S,3S)-1,2-epoxy-3-hydroxypentane (111900-48-2) → 4-Nitro-benzoic acid (R)-1-[(2S,7R)-7-((R)-2-acetoxy-1-methanesulfonyloxy-ethyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-propyl ester (326853-52-5)

Guidance literature:

Multi-step reaction with 13 steps

1.1: 89 percent / i-Pr₂NEt; DMAP / 1,2-dichloro-ethane / 50 °C

2.1: 91 percent / dimethylsulfoxide / 0 °C

3.1: 79 percent / NaH / tetrahydrofuran

4.1: 76 percent / n-BuLi; BF₃*OEt₂ / tetrahydrofuran / -78 °C

5.1: 99 percent / DMAP; Pyridine / CH₂Cl₂

6.1: 85 percent / TBAF / tetrahydrofuran

7.1: 99 percent / H₂ / Lindlar catalyst / methanol

8.1: (Bu₃Sn)2O / toluene / Heating

8.2: 97 percent / Zn(OTf)2 / 90 °C

9.1: 99 percent / TEA; DMAP / CH₂Cl₂

10.1: 81 percent / ZnBr₂ / 1,2-dichloro-ethane

11.1: 82 percent / DEAD; Ph₃P / tetrahydrofuran

12.1: PhSTMS; ZnI₂; Bu₄I / CH₂Cl₂

12.2: TBAF / tetrahydrofuran

12.3: silica gel / CH₂Cl₂

13.1: TEA; DMAP / CH₂Cl₂

With pyridine; dmap; n-butyllithium; phenylthiotrimethylsilane; TEA; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; bis(tri-n-butyltin)oxide; zinc(II) iodide; zinc dibromide; diethylazodicarboxylate; Lindlar's catalyst; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane; toluene; 4.1: Yamaguchi reaction / 11.1: Mitsunobu reaction / 12.1: Nicolaou reaction;

DOI:10.1016/S0040-4039(00)01880-3

upstream raw materials:

(4S,5S)-4-ethyl-5-hydroxymethyl-1,3-dioxolane

(4S,5S)-(-)-5-Ethyl-2,2-dimethyl-4-(tosyloxymethyl)-1,3-dioxolan

(2S,3S)-1,2-epoxy-3-hydroxypentane

(4S,5S)-4-Benzyloxymethyl-5-ethyl-2,2-dimethyl-[1,3]dioxolane

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 326853-52-5 4-Nitro-benzoic acid (R)-1-[(2S,7R)-7-((R)-2-acetoxy-1-methanesulfonyloxy-ethyl)-2,3,6,7-tetrahydro-oxepin-2-yl]-propyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send