C₁₅H₁₃FO₂

Base Information

• Chemical Name: C₁₅H₁₃FO₂
• CAS No.: 1142210-78-3
• Molecular Formula: C₁₅H₁₃FO₂
• Molecular Weight: 244.265
• Mol file: 1142210-78-3.mol

Synonyms:

Chemical Property of C₁₅H₁₃FO₂

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

3-(2-Fluorophenyl)-3-phenylpropanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₅H₁₃FO₂

There total 12 articles about C₁₅H₁₃FO₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(Z)-3-(2-fluorophenyl)-3-phenylacrylic acid → (S)-3-(2-fluorophenyl)-3-phenylpropanoic acid (1142210-78-3)

Guidance literature:

With chloro(1,5-cyclooctadiene)rhodium(I) dimer; (R,R)-f-spiroPhos; hydrogen; In dichloromethane; at 0 - 20 ℃; for 4h; under 7600.51 Torr; enantioselective reaction; Autoclave;

DOI:10.1021/acs.joc.6b00018

Reference yield: 82.0%

C16H15FO2 → C15H13FO2 (1142210-78-3)

Guidance literature:

With potassium hydroxide; In ethanol; water; at 0 - 20 ℃; for 1h;

DOI:10.1016/j.ejmech.2018.11.050

Reference yield:

(E)-3-(2-fluorophenyl)-3-phenylacrylic acid → (R)-3-(2-fluorophenyl)-3-phenylpropanoic acid (1142210-78-3)

Guidance literature:

(E)-3-(2-fluorophenyl)-3-phenylacrylic acid; With morpholine; In water; isopropyl alcohol; at 20 ℃; for 0.166667h; Schlenk technique;

With bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; C₂₄H₂₁O₃P; hydrogen; triphenylphosphine; In water; isopropyl alcohol; at 20 ℃; for 16h; under 19001.3 Torr; enantioselective reaction; Autoclave; Glovebox;

DOI:10.1002/anie.201302349

upstream raw materials:

(E)-ethyl 3-(2-fluorophenyl)-3-phenylacrylate

phenylpropynoic acid ethyl ester

o-fluorophenylboronic acid

ethyl 3-iodo-3-phenylacrylate

Refernces

• 1、 Yan, Qiaozhi,Kong, Duanyang,Zhao, Wei,Zi, Guofu,Hou, Guohua. "Enantioselective Hydrogenation of β,β-Disubstituted Unsaturated Carboxylic Acids under Base-Free Conditions". . p. 2070 - 2077. Retrieved 2016/03/15.