C₅₂H₆₄N₄O₇

Base Information

• Chemical Name: C₅₂H₆₄N₄O₇
• CAS No.: 1374647-07-0
• Molecular Formula: C₅₂H₆₄N₄O₇
• Molecular Weight: 857.103
• Mol file: 1374647-07-0.mol

Synonyms:

Chemical Property of C₅₂H₆₄N₄O₇

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₂H₆₄N₄O₇

There total 5 articles about C₅₂H₆₄N₄O₇ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4R,5R)-3-benzyl-5-{(1S)-1-[(tert-butoxycarbonyl)amino]-2-phenylethyl}dihydrofuran-2-(3H)-one (98737-42-9) → C52H64N4O7 (1374647-07-0)

Guidance literature:

Multi-step reaction with 4 steps

1: water; lithium hydroxide / 1,2-dimethoxyethane

2: 1H-imidazole / N,N-dimethyl-formamide

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

4: tetrabutyl ammonium fluoride / tetrahydrofuran

With 1H-imidazole; tetrabutyl ammonium fluoride; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.02.027

Reference yield:

C33H43N3O5 (1392212-55-3) → C52H64N4O7 (1374647-07-0)

Guidance literature:

Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

3: tetrabutyl ammonium fluoride / tetrahydrofuran

With tetrabutyl ammonium fluoride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.02.027

Reference yield:

1-amino-5-hexyne (15252-45-6) → C52H64N4O7 (1374647-07-0)

Guidance literature:

Multi-step reaction with 4 steps

1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

2: trifluoroacetic acid / dichloromethane

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

4: tetrabutyl ammonium fluoride / tetrahydrofuran

With HATU; tetrabutyl ammonium fluoride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.02.027

upstream raw materials:

C₃₃H₄₃N₃O₅

C₂₈H₃₅N₃O₃

(2R,4R,5S)-2-benzyl-5-tert-butoxycarbonylamino-4-(tert-butyldimethylsilyloxy)-6-phenylhexanoic acid

2-(hex-5-yn-1-yl)isoindole-1,3-dione