1-[(4-chlorobenzyl)oxy]-4-methoxybenzene

Base Information

• Chemical Name: 1-[(4-chlorobenzyl)oxy]-4-methoxybenzene
• CAS No.: 112944-92-0
• Molecular Formula: C14H13ClO2
• Molecular Weight: 248.709
• Mol file: 112944-92-0.mol

Synonyms:1-(4-chloro-benzyloxy)-4-methoxy-benzene;.O-Methyl-O'-(4-chlor-benzyl)-hydrochinon;.1-(4-Chlor-benzyloxy)-4-methoxy-benzol;

Chemical Property of 1-[(4-chlorobenzyl)oxy]-4-methoxybenzene

Chemical Property:

• PSA: 18.46000
• LogP: 3.92760

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-[(4-chlorobenzyl)oxy]-4-methoxybenzene

There total 3 articles about 1-[(4-chlorobenzyl)oxy]-4-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-methoxy-phenol (150-76-5) + 4-chlorobenzyl diphenylphosphinite (910212-97-4) → 4-chlorobenzyl 4-methoxyphenyl ether (112944-92-0)

Guidance literature:

With 2,6-dimethyl-1,4-benzoquinone; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1021/ja0487877

Reference yield:

sodium 4-methoxyphenolate (1122-95-8) + C14H14ClS(1+)*BF4(1-) → methyl-phenyl-thioether (100-68-5) + 4-chlorobenzyl 4-methoxyphenyl ether (112944-92-0)

Guidance literature:

In d⁽⁴⁾-methanol; at 30 ℃; Kinetics;

DOI:10.1021/jo981902+

Reference yield:

para-Chlorobenzyl alcohol (873-76-7) → 4-chlorobenzyl 4-methoxyphenyl ether (112944-92-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 1 h / 20 °C

1.2: tetrahydrofuran; hexane / 1 h / 20 °C

2.1: 91 percent / 2,6-dimethyl-1,4-benzoquinone / CH₂Cl₂ / 1 h / 20 °C

With n-butyllithium; 2,6-dimethyl-1,4-benzoquinone; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1021/ja0487877

upstream raw materials:

sodium 4-methoxyphenolate

4-methoxy-phenol

4-chlorobenzyl diphenylphosphinite

para-Chlorobenzyl alcohol