Technology Process of (E)-N-hydroxy-4-methoxy-2-(naphthalen-1-yl)cinnamamide
There total 6 articles about (E)-N-hydroxy-4-methoxy-2-(naphthalen-1-yl)cinnamamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydroxylamine hydrochloride; potassium hydroxide;
In
methanol;
at 20 ℃;
for 3h;
DOI:10.1002/cmdc.201200300
- Guidance literature:
-
Multi-step reaction with 2 steps
1: triethylamine / tetrahydrofuran / 1 h / 20 °C
2: hydroxylamine hydrochloride; potassium hydroxide / methanol / 3 h / 20 °C
With
hydroxylamine hydrochloride; triethylamine; potassium hydroxide;
In
tetrahydrofuran; methanol;
DOI:10.1002/cmdc.201200300
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 6 h / Inert atmosphere
2: pyridine / dichloromethane / 2 h / 20 °C
3: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / N,N-dimethyl-formamide / 12 h / 90 °C
4: lithium hydroxide / methanol
5: triethylamine / tetrahydrofuran / 1 h / 20 °C
6: hydroxylamine hydrochloride; potassium hydroxide / methanol / 3 h / 20 °C
With
pyridine; tetrakis(triphenylphosphine) palladium(0); hydroxylamine hydrochloride; potassium carbonate; triethylamine; potassium hydroxide; lithium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
3: |Suzuki-Miyaura Coupling;
DOI:10.1002/cmdc.201200300
