Technology Process of diphenyl α-N-(propiolamido)(4-guanidiniumphenyl)methanephosphonate
There total 6 articles about diphenyl α-N-(propiolamido)(4-guanidiniumphenyl)methanephosphonate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Propiolic acid;
With
diisopropyl-carbodiimide;
In
tetrahydrofuran;
C20H21N4O3P*BrH;
In
N,N-dimethyl-formamide;
at 20 ℃;
DOI:10.1039/c3ob40907d
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: acetic acid / 2 h / 82 °C
2.1: acetic acid; iron / 70 °C / Inert atmosphere
3.1: mercury dichloride; triethylamine / dichloromethane
4.1: acetic acid; hydrogen bromide / 20 °C
5.1: diisopropyl-carbodiimide / tetrahydrofuran
5.2: tertiary amine / 20 °C
With
hydrogen bromide; iron; acetic acid; triethylamine; mercury dichloride; diisopropyl-carbodiimide;
In
tetrahydrofuran; dichloromethane;
DOI:10.1039/c3ob40907d
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: mercury dichloride; triethylamine / dichloromethane
2.1: acetic acid; hydrogen bromide / 20 °C
3.1: diisopropyl-carbodiimide / tetrahydrofuran
3.2: tertiary amine / 20 °C
With
hydrogen bromide; acetic acid; triethylamine; mercury dichloride; diisopropyl-carbodiimide;
In
tetrahydrofuran; dichloromethane;
DOI:10.1039/c3ob40907d
