2-[4-(2-fluorobenzyl)piperazin-1-yl]-N-(1-phenyl-1,4-dihydrothieno[3',2':4,5]cyclopenta[1,2-c]pyrazol-4-yl)acetamide

Base Information

• Chemical Name: 2-[4-(2-fluorobenzyl)piperazin-1-yl]-N-(1-phenyl-1,4-dihydrothieno[3',2':4,5]cyclopenta[1,2-c]pyrazol-4-yl)acetamide
• CAS No.: 1459701-27-9
• Molecular Formula: C₂₇H₂₆FN₅OS
• Molecular Weight: 487.601
• Mol file: 1459701-27-9.mol

Synonyms:

Chemical Property of 2-[4-(2-fluorobenzyl)piperazin-1-yl]-N-(1-phenyl-1,4-dihydrothieno[3',2':4,5]cyclopenta[1,2-c]pyrazol-4-yl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[4-(2-fluorobenzyl)piperazin-1-yl]-N-(1-phenyl-1,4-dihydrothieno[3',2':4,5]cyclopenta[1,2-c]pyrazol-4-yl)acetamide

There total 5 articles about 2-[4-(2-fluorobenzyl)piperazin-1-yl]-N-(1-phenyl-1,4-dihydrothieno[3',2':4,5]cyclopenta[1,2-c]pyrazol-4-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

2-chloro-N-(1-phenyl-1,4-dihydrothieno[3',2':4,5]cyclopenta[1,2-c]pyrazol-4-yl)acetamide (1459701-09-7) + 1-(o-fluorobenzyl)piperazine (89292-78-4) → 2-[4-(2-fluorobenzyl)piperazin-1-yl]-N-(1-phenyl-1,4-dihydrothieno[3',2':4,5]cyclopenta[1,2-c]pyrazol-4-yl)acetamide (1459701-27-9)

Guidance literature:

With potassium carbonate; In acetone; for 12h; Reflux;

DOI:10.1039/c3md00041a

Reference yield:

2,2,2-trifluoro-N-(5,6-dihydro-6-oxo-4H-cyclopenta[b]thiophen-4-yl)acetamide (108046-14-6) → 2-[4-(2-fluorobenzyl)piperazin-1-yl]-N-(1-phenyl-1,4-dihydrothieno[3',2':4,5]cyclopenta[1,2-c]pyrazol-4-yl)acetamide (1459701-27-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: N,N-dimethyl acetamide / toluene / 8 h / Reflux

2.1: acetic acid / 4 h / Reflux

3.1: hydrogenchloride / water / 2 h / Reflux

4.1: triethylamine / dichloromethane / 0.08 h

4.2: 0 - 20 °C

5.1: potassium carbonate / acetone / 12 h / Reflux

With hydrogenchloride; N,N-dimethyl acetamide; potassium carbonate; acetic acid; triethylamine; In dichloromethane; water; acetone; toluene;

DOI:10.1039/c3md00041a

Reference yield:

1-phenyl-1,4-dihydrothieno[3',2':4,5]cyclopenta[1,2-c]pyrazol-4-amine dihydrochloride → 2-[4-(2-fluorobenzyl)piperazin-1-yl]-N-(1-phenyl-1,4-dihydrothieno[3',2':4,5]cyclopenta[1,2-c]pyrazol-4-yl)acetamide (1459701-27-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0.08 h

1.2: 0 - 20 °C

2.1: potassium carbonate / acetone / 12 h / Reflux

With potassium carbonate; triethylamine; In dichloromethane; acetone;

DOI:10.1039/c3md00041a

upstream raw materials:

2,2,2-trifluoro-N-(1-phenyl-1,4-dihydrothieno[3',2':4,5]cyclopenta[1,2-c]pyrazol-4-yl)acetamide

2,2,2-trifluoro-N-(5,6-dihydro-6-oxo-4H-cyclopenta[b]thiophen-4-yl)acetamide

2-chloro-N-(1-phenyl-1,4-dihydrothieno[3',2':4,5]cyclopenta[1,2-c]pyrazol-4-yl)acetamide

1-(o-fluorobenzyl)piperazine