4-METHYL-2-PYRIDYLMAGNESIUM BROMIDE

Base Information

• Chemical Name: 4-METHYL-2-PYRIDYLMAGNESIUM BROMIDE
• CAS No.: 113170-67-5
• Molecular Formula: C6H6BrMgN
• Molecular Weight: 196.32800
• Mol file: 113170-67-5.mol

Synonyms:4-methyl-2-pyridinylmagnesium bromide;4-Methyl-2-pyridylmagnesium bromide 0.25 M in Tetrahydrofuran;

Chemical Property of 4-METHYL-2-PYRIDYLMAGNESIUM BROMIDE

Chemical Property:

• PSA: 12.89000
• LogP: 2.03580

Purity/Quality:

98%min ^*data from raw suppliers

4-Methylpyridin-2-ylmagnesiumbromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-METHYL-2-PYRIDYLMAGNESIUM BROMIDE

There total 1 articles about 4-METHYL-2-PYRIDYLMAGNESIUM BROMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Bromo-4-picoline (4926-28-7) + isopropylmagnesium chloride (1068-55-9) → (4-methyl-2-pyridyl)magnesium bromide (113170-67-5)

Guidance literature:

In tetrahydrofuran; at 0 - 15 ℃; for 4h;

Reference yield: 84.0%

(4-methyl-2-pyridyl)magnesium bromide (113170-67-5) + ortho-methylphenyl iodide (615-37-2) → 2-(2-methylphenyl)-4-methylpyridine (64291-98-1)

Guidance literature:

ortho-methylphenyl iodide; With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bis(1-adamantyl)phosphine oxide; In tetrahydrofuran; for 0.0833333h; Inert atmosphere;

(4-methyl-2-pyridyl)magnesium bromide; In tetrahydrofuran; at 60 ℃; for 20h; chemoselective reaction; Inert atmosphere;

DOI:10.1002/chem.201000032

Reference yield: 84.0%

(4-methyl-2-pyridyl)magnesium bromide (113170-67-5) + 1-bromo-4-tert-butylbenzene (3972-65-4) → 4-methyl-2-(4-tert-butylphenyl)pyridine (1226769-59-0)

Guidance literature:

With C₄₂H₆₄O₄P₂Pd; In tetrahydrofuran; at 60 ℃; for 20h; chemoselective reaction; Inert atmosphere;

DOI:10.1002/chem.201000032

upstream raw materials:

2-Bromo-4-picoline

isopropylmagnesium chloride

Downstream raw materials:

4-methyl-2-pyridinecarbaldehyde

2-(2-methylphenyl)-4-methylpyridine

4-methyl-2-(4-tert-butylphenyl)pyridine

4-methyl-2-[4-(trifluoromethyl)phenyl]pyridine