(4R,6R,1'RS,1RS)-4-<(tert-butyldimethylsilyl)oxy>-6-<2-(1,2,3,4-tetrahydro-7-phenyl-1-naphthyl)-1-iodoethyl>-3,4,5,6-tetrahydro-2H-pyran-2-one

Base Information

Chemical Name:(4R,6R,1'RS,1RS)-4-<(tert-butyldimethylsilyl)oxy>-6-<2-(1,2,3,4-tetrahydro-7-phenyl-1-naphthyl)-1-iodoethyl>-3,4,5,6-tetrahydro-2H-pyran-2-one
CAS No.:137848-05-6
Molecular Formula:C₂₉H₃₉IO₃Si
Molecular Weight:590.617
Hs Code.:

(4R,6R,1'RS,1RS)-4-<(tert-butyldimethylsilyl)oxy>-6-<2-(1,2,3,4-tetrahydro-7-phenyl-1-naphthyl)-1-iodoethyl>-3,4,5,6-tetrahydro-2H-pyran-2-one

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Chemical Property of (4R,6R,1'RS,1RS)-4-<(tert-butyldimethylsilyl)oxy>-6-<2-(1,2,3,4-tetrahydro-7-phenyl-1-naphthyl)-1-iodoethyl>-3,4,5,6-tetrahydro-2H-pyran-2-one

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Technology Process of (4R,6R,1'RS,1RS)-4-<(tert-butyldimethylsilyl)oxy>-6-<2-(1,2,3,4-tetrahydro-7-phenyl-1-naphthyl)-1-iodoethyl>-3,4,5,6-tetrahydro-2H-pyran-2-one

There total 22 articles about (4R,6R,1'RS,1RS)-4-<(tert-butyldimethylsilyl)oxy>-6-<2-(1,2,3,4-tetrahydro-7-phenyl-1-naphthyl)-1-iodoethyl>-3,4,5,6-tetrahydro-2H-pyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 137848-03-4,137848-13-6
(3R,1'RS)-(Z)-3-<(tert-butyldimethylsilyl)oxy>-7-(1,2,3,4-tetrahydro-7-methoxy-1-naphthyl)-5-heptenoic acid

: 137848-05-6,137939-80-1,137939-81-2,137939-82-3,137939-83-4,137939-84-5,137939-85-6,137940-83-1
(4R,6S,1'RS,1RS)-4-<(tert-butyldimethylsilyl)oxy>-6-<2-(1,2,3,4-tetrahydro-7-phenyl-1-naphthyl)-1-iodoethyl>-3,4,5,6-tetrahydro-2H-pyran-2-one

: 137848-05-6,137939-80-1,137939-81-2,137939-82-3,137939-83-4,137939-84-5,137939-85-6,137940-83-1
(4R,6R,1'RS,1RS)-4-<(tert-butyldimethylsilyl)oxy>-6-<2-(1,2,3,4-tetrahydro-7-phenyl-1-naphthyl)-1-iodoethyl>-3,4,5,6-tetrahydro-2H-pyran-2-one

Guidance literature:: With iodine; sodium hydrogencarbonate; potassium iodide; In tetrahydrofuran; water; for 3h; Ambient temperature;

Reference yield: 17.0%

: 137848-03-4,137848-13-6
(3R,1'RS)-(Z)-3-<(tert-butyldimethylsilyl)oxy>-7-(1,2,3,4-tetrahydro-7-methoxy-1-naphthyl)-5-heptenoic acid

: 137848-05-6,137939-80-1,137939-81-2,137939-82-3,137939-83-4,137939-84-5,137939-85-6,137940-83-1
(4R,6S,1'RS,1RS)-4-<(tert-butyldimethylsilyl)oxy>-6-<2-(1,2,3,4-tetrahydro-7-phenyl-1-naphthyl)-1-iodoethyl>-3,4,5,6-tetrahydro-2H-pyran-2-one

: 137848-05-6,137939-80-1,137939-81-2,137939-82-3,137939-83-4,137939-84-5,137939-85-6,137940-83-1
(4R,6R,1'RS,1RS)-4-<(tert-butyldimethylsilyl)oxy>-6-<2-(1,2,3,4-tetrahydro-7-phenyl-1-naphthyl)-1-iodoethyl>-3,4,5,6-tetrahydro-2H-pyran-2-one

Guidance literature:: With iodine; sodium hydrogencarbonate; potassium iodide; In tetrahydrofuran; water; for 3h; Ambient temperature;

Reference yield:

: 6836-19-7
7-Methoxy-1-tetralone

: 137848-05-6,137939-80-1,137939-81-2,137939-82-3,137939-83-4,137939-84-5,137939-85-6,137940-83-1
(4R,6S,1'RS,1RS)-4-<(tert-butyldimethylsilyl)oxy>-6-<2-(1,2,3,4-tetrahydro-7-phenyl-1-naphthyl)-1-iodoethyl>-3,4,5,6-tetrahydro-2H-pyran-2-one

Guidance literature:: Multi-step reaction with 8 steps

1: 1) LDA / 1) THF, hexane, -78 deg C, 10 min, 2) a) -78 deg C, 2 h, b) -20 deg C, 2 h, c) to r.t., 2 h

2: 85 percent / H₂ / Pd/C / ethanol / 4 h

3: 92 percent / LiAlH₄ / diethyl ether / 2 h / 0 °C

4: 89 percent / pyridine, PBr₃ / benzene / 6 h / Ambient temperature

5: 98 percent / acetonitrile / 40 h / Heating

6: 1) n-BuLi / 1) THF, hexane, -20 deg C, 1 h, 2) 0 deg C, 2 h

7: 855 percent / 6.7percent NaOH / ethanol / 4 h / Heating

8: 41 percent / I₂, KI, NaHCO₃ / tetrahydrofuran; H₂O / 3 h / Ambient temperature

With pyridine; sodium hydroxide; lithium aluminium tetrahydride; n-butyllithium; hydrogen; iodine; phosphorus tribromide; sodium hydrogencarbonate; potassium iodide; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; water; acetonitrile; benzene;