3-[2-(4-fluorophenyl)-2-oxoethyl]-3-hydroxy-1,3-dihydro-2H-indol-2-one

Base Information

• Chemical Name: 3-[2-(4-fluorophenyl)-2-oxoethyl]-3-hydroxy-1,3-dihydro-2H-indol-2-one
• CAS No.: 113333-93-0
• Molecular Formula: C16H12FNO3
• Molecular Weight: 285.275
• Mol file: 113333-93-0.mol

Synonyms:1,3-dihydro-3-hydroxy-3-[2-(4-fluorophenyl)-2-oxoethylidene]-indol-2(1H)-one;3-[2-(4-fluorophenyl)-2-oxoethyl]-3-hydroxy-1,3-dihydro-2H-indol-2-one;1,3-dihydro-3-hydroxy-3-<2-(4-fluorophenyl)-2-oxoethyl>-2H-indol-2-one;3-(2-(4-fluorophenyl)-2-oxoethyl)-3-hydroxyindolin-2-one;3-hydroxy-3-(2-oxo-2-(4-fluorophenyl)ethyl)indolin-2-one;2H-indol-2-one,3-[2-(4-fluorophenyl)-2-oxoethyl]-1,3-dihydro-3-hydroxy;3-hydroxy-3-(4-fluorophenacyl)-indol-2-one;

Chemical Property of 3-[2-(4-fluorophenyl)-2-oxoethyl]-3-hydroxy-1,3-dihydro-2H-indol-2-one

Chemical Property:

• PSA: 69.89000
• LogP: 2.32350

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-[2-(4-fluorophenyl)-2-oxoethyl]-3-hydroxy-1,3-dihydro-2H-indol-2-one

There total 4 articles about 3-[2-(4-fluorophenyl)-2-oxoethyl]-3-hydroxy-1,3-dihydro-2H-indol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) + 3-(4-fluorophenyl)-3-oxopropanoic acid (80646-00-0) → 1,3-dihydro-3-hydroxy-3-<2-(4-fluorophenyl)-2-oxoethyl>-2H-indol-2-one (113333-93-0)

Guidance literature:

In ethyl acetate; at 20 ℃; for 1h; Molecular sieve; Sealed tube;

DOI:10.1016/j.tetlet.2013.06.030

Reference yield: 89.76%

indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) + 1-(4-fluorophenyl)ethanone (403-42-9) → 1,3-dihydro-3-hydroxy-3-<2-(4-fluorophenyl)-2-oxoethyl>-2H-indol-2-one (113333-93-0)

Guidance literature:

With diethylamine; In ethanol; for 0.5h; Reflux;

DOI:10.1002/cmdc.201500443

Reference yield:

hydroxyimino-N-phenylacetamide (42366-35-8,1769-41-1) → 1,3-dihydro-3-hydroxy-3-<2-(4-fluorophenyl)-2-oxoethyl>-2H-indol-2-one (113333-93-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 1.25 h / 60 - 80 °C

2: ethanol / 20 °C

With sulfuric acid; In ethanol;

DOI:10.1016/j.ejmech.2017.12.043

upstream raw materials:

indole-2,3-dione

1-(4-fluorophenyl)ethanone

3-(4-fluorophenyl)-3-oxopropanoic acid

aniline

Downstream raw materials:

2-(4-fluorobenzoyl)-spiro-2'(1'H)-one

6-(4-fluorophenyl)-1,3-dimethyl-5-(2-oxoindolin-3-yl)-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione

6-(4-fluorophenyl)-5-(2-oxoindolin-3-yl)-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione

3-(4-fluorophenyl)-9-acetyl-pyridazino[3,4-b]indole

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