3-methylphenyl 1-(2,6-dimethylphenyl)-2-phenyl-4-trifluoromethyl-5-imidazolyl sulfone

Base Information

• Chemical Name: 3-methylphenyl 1-(2,6-dimethylphenyl)-2-phenyl-4-trifluoromethyl-5-imidazolyl sulfone
• CAS No.: 1026897-85-7
• Molecular Formula: C₂₅H₂₁F₃N₂O₂S
• Molecular Weight: 470.515
• Mol file: 1026897-85-7.mol

Synonyms:

Chemical Property of 3-methylphenyl 1-(2,6-dimethylphenyl)-2-phenyl-4-trifluoromethyl-5-imidazolyl sulfone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-methylphenyl 1-(2,6-dimethylphenyl)-2-phenyl-4-trifluoromethyl-5-imidazolyl sulfone

There total 3 articles about 3-methylphenyl 1-(2,6-dimethylphenyl)-2-phenyl-4-trifluoromethyl-5-imidazolyl sulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

3-methylphenyl 1-(2,6-dimethylphenyl)-2-phenyl-4-trifluoromethyl-5-imidazolyl sulfide → 3-methylphenyl 1-(2,6-dimethylphenyl)-2-phenyl-4-trifluoromethyl-5-imidazolyl sulfone (1026897-85-7)

Guidance literature:

With dihydrogen peroxide; acetic acid; at 90 ℃;

DOI:10.1002/jhet.5570310248

Reference yield:

toluene-3-thiol (108-40-7) → 3-methylphenyl 1-(2,6-dimethylphenyl)-2-phenyl-4-trifluoromethyl-5-imidazolyl sulfone (1026897-85-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 42 percent / diazabicycloundecene / dimethylsulfoxide / 144 h / 50 °C

2: 64 percent / 30percent aq. H₂O₂, glacial acetic acid / 90 °C

With dihydrogen peroxide; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dimethyl sulfoxide;

DOI:10.1002/jhet.5570310248

Reference yield:

1-(2,6-Dimethylphenyl)-5-fluoro-2-phenyl-4-(trifluoromethyl)-imidazole (70276-86-7) → 3-methylphenyl 1-(2,6-dimethylphenyl)-2-phenyl-4-trifluoromethyl-5-imidazolyl sulfone (1026897-85-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 42 percent / diazabicycloundecene / dimethylsulfoxide / 144 h / 50 °C

2: 64 percent / 30percent aq. H₂O₂, glacial acetic acid / 90 °C

With dihydrogen peroxide; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dimethyl sulfoxide;

DOI:10.1002/jhet.5570310248

upstream raw materials:

toluene-3-thiol

1-(2,6-Dimethylphenyl)-5-fluoro-2-phenyl-4-(trifluoromethyl)-imidazole

Downstream raw materials:

N-trifluoroacetyl-4-(hydroxymethyl)piperidine