benzyl 2-(4-(4-fluoro(benzyl-d6)carbamoyl)-5-hydroxy-1-(methyl-d3)-6-oxo-1,6-dihydropyrimidin-2-yl)-(1,3-d6-propan)-2-ylcarbamate

Base Information

• Chemical Name: benzyl 2-(4-(4-fluoro(benzyl-d6)carbamoyl)-5-hydroxy-1-(methyl-d3)-6-oxo-1,6-dihydropyrimidin-2-yl)-(1,3-d6-propan)-2-ylcarbamate
• CAS No.: 1189916-86-6
• Molecular Formula: C₂₄H₂₅FN₄O₅
• Molecular Weight: 483.366
• Mol file: 1189916-86-6.mol

Synonyms:

Chemical Property of benzyl 2-(4-(4-fluoro(benzyl-d6)carbamoyl)-5-hydroxy-1-(methyl-d3)-6-oxo-1,6-dihydropyrimidin-2-yl)-(1,3-d6-propan)-2-ylcarbamate

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Benzyl[1-[4-[[(4-Fluorobenzyl)amino]carbonyl]-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl]-1-methylethyl]carbamate-d3 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl 2-(4-(4-fluoro(benzyl-d6)carbamoyl)-5-hydroxy-1-(methyl-d3)-6-oxo-1,6-dihydropyrimidin-2-yl)-(1,3-d6-propan)-2-ylcarbamate

There total 2 articles about benzyl 2-(4-(4-fluoro(benzyl-d6)carbamoyl)-5-hydroxy-1-(methyl-d3)-6-oxo-1,6-dihydropyrimidin-2-yl)-(1,3-d6-propan)-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methyl 2-(2-(benzyloxycarbonylamino)-(1,3-d6-propan)-2-yl)-5-hydroxy-1-(methyl-d3)-6-oxo-1,6-dihydropyrimidine-4-carboxylate (1100750-74-0) + para-fluorobenzylamine (140-75-0) → benzyl 2-(4-(4-fluorobenzylcarbamoyl)-5-hydroxy-1-(methyl-d3)-6-oxo-1,6-dihydropyrimidin-2-yl)-(1,3-d6-propan)-2-ylcarbamate (1100750-79-5,1189916-86-6)

Guidance literature:

With triethylamine; In ethanol; at 0 - 72 ℃; for 2h;

Reference yield: 80.0%

(4-fluorophenyl-d4)-(methan-d2)amine hydrochloride (1100750-66-0) + methyl 2-(2-(benzyloxycarbonylamino)-(1,3-d6-propan)-2-yl)-5-hydroxy-1-(methyl-d3)-6-oxo-1,6-dihydropyrimidine-4-carboxylate (1100750-74-0) → benzyl 2-(4-(4-fluoro(benzyl-d6)carbamoyl)-5-hydroxy-1-(methyl-d3)-6-oxo-1,6-dihydropyrimidin-2-yl)-(1,3-d6-propan)-2-ylcarbamate (1100750-75-1,1189916-86-6)

Guidance literature:

With triethylamine; In ethanol; at 0 - 72 ℃; for 2h;

upstream raw materials:

methyl 2-(2-(benzyloxycarbonylamino)-(1,3-d6-propan)-2-yl)-5-hydroxy-1-(methyl-d3)-6-oxo-1,6-dihydropyrimidine-4-carboxylate

para-fluorobenzylamine

(4-fluorophenyl-d4)-(methan-d2)amine hydrochloride