1,3-BispalMitoyl-2-chloropropanediol

Base Information

• Chemical Name: 1,3-BispalMitoyl-2-chloropropanediol
• CAS No.: 169471-41-4
• Molecular Formula: C₃₅H₆₇ClO₄
• Molecular Weight: 587.368
• Mol file: 169471-41-4.mol

Synonyms:

Chemical Property of 1,3-BispalMitoyl-2-chloropropanediol

Chemical Property:

• Melting Point: 41 - 43°C
• Boiling Point: 630.7±35.0 °C(Predicted)
• Density: 0.939±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

1,3-Dipalmitoyl-2-chloropropanediol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 1,3-Dipalmitoyl-2-chloropropanediol is used in the synthesis of some prodrugs of Piroxicam and Lornoxicam to improve their bioavailability.

Technology Process of 1,3-BispalMitoyl-2-chloropropanediol

There total 2 articles about 1,3-BispalMitoyl-2-chloropropanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

hexadecanoic acid, 2-hydroxy-1,3-propanediyl ester (502-52-3) → 2-chloro-1,3-(dipalmitoyloxy)propane (169471-41-4)

Guidance literature:

With thionyl chloride; In chloroform; for 2h; Heating;

Reference yield:

2-chloro-propane-1,3-diol (497-04-1) + 1-hexadecylcarboxylic acid (57-10-3) → 2-chloro-1,3-(dipalmitoyloxy)propane (169471-41-4)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃;

DOI:10.1021/acs.jafc.9b01083

upstream raw materials:

hexadecanoic acid, 2-hydroxy-1,3-propanediyl ester

2-chloro-propane-1,3-diol

1-hexadecylcarboxylic acid

Refernces

• 1、 Passarotti,Valenti,Grianti. "Oxicam pro-drugs. Nota 1. Synthesis of some prodrugs of piroxicam and lornoxicam". . p. 161 - 165. Retrieved 2007/10/02.