Technology Process of 6α-hydroxy-9-methyl-5-tosyl-6aβ,7,8,10aβ-tetrahydro-indeno<2,1-b>indole
There total 7 articles about 6α-hydroxy-9-methyl-5-tosyl-6aβ,7,8,10aβ-tetrahydro-indeno<2,1-b>indole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium (hydro)trimethoxyaluminate;
In
tetrahydrofuran;
for 0.5h;
Ambient temperature;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: NaH / 1,2-dimethoxy-ethane
2: tetrahydrofuran
3: 60 percent / mesyl chloride, triethylamine / tetrahydrofuran / 1.) -60 deg C to r.t., 1.5 h, 2.) r.t., 0.5 h, 3.) reflux, 20 min
4: 63 percent / benzene / 3 h / Heating
5: 60 percent / polyphoshate ester / CHCl3 / 0.5 h / Heating
6: 75 percent / Li(MeO) 3AlH / tetrahydrofuran / 0.5 h / Ambient temperature
With
polyphoshate ester; sodium hydride; methanesulfonyl chloride; lithium (hydro)trimethoxyaluminate; triethylamine;
In
tetrahydrofuran; 1,2-dimethoxyethane; chloroform; benzene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: tetrahydrofuran
2: 60 percent / mesyl chloride, triethylamine / tetrahydrofuran / 1.) -60 deg C to r.t., 1.5 h, 2.) r.t., 0.5 h, 3.) reflux, 20 min
3: 63 percent / benzene / 3 h / Heating
4: 60 percent / polyphoshate ester / CHCl3 / 0.5 h / Heating
5: 75 percent / Li(MeO) 3AlH / tetrahydrofuran / 0.5 h / Ambient temperature
With
polyphoshate ester; methanesulfonyl chloride; lithium (hydro)trimethoxyaluminate; triethylamine;
In
tetrahydrofuran; chloroform; benzene;
