Phosphorous acid 2-cyano-ethyl ester bis-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yl) ester

Base Information

• Chemical Name: Phosphorous acid 2-cyano-ethyl ester bis-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yl) ester
• CAS No.: 103866-98-4
• Molecular Formula: C₅₇H₆₂NO₁₁P
• Molecular Weight: 968.093
• Mol file: 103866-98-4.mol

Synonyms:

Chemical Property of Phosphorous acid 2-cyano-ethyl ester bis-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phosphorous acid 2-cyano-ethyl ester bis-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yl) ester

There total 1 articles about Phosphorous acid 2-cyano-ethyl ester bis-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3,4-tri-O-benzyl-6-deoxy-α-L-galactopyranose (33639-75-7) → Phosphorous acid 2-cyano-ethyl ester bis-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yl) ester (103866-98-4)

Guidance literature:

Multi-step reaction with 2 steps

1: iPr₂NEt / CH₂Cl₂ / 0.33 h / 20 °C

2: 1H-tetrazole

With 1H-tetrazole; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1016/S0040-4039(00)84219-7

Reference yield:

Phosphorous acid 2-cyano-ethyl ester bis-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yl) ester (103866-98-4) → Phosphoric acid 2-cyano-ethyl ester bis-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yl) ester (103866-99-5)

Guidance literature:

With tert.-butylhydroperoxide;

DOI:10.1016/S0040-4039(00)84219-7

upstream raw materials:

2,3,4-tri-O-benzyl-6-deoxy-α-L-galactopyranose

Downstream raw materials:

Phosphoric acid 2-cyano-ethyl ester bis-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yl) ester