C₂₇H₃₄Cl₂N₂O₆

Base Information

• Chemical Name: C₂₇H₃₄Cl₂N₂O₆
• CAS No.: 1265907-56-9
• Molecular Formula: C₂₇H₃₄Cl₂N₂O₆
• Molecular Weight: 553.483
• Mol file: 1265907-56-9.mol

Synonyms:

Chemical Property of C₂₇H₃₄Cl₂N₂O₆

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₇H₃₄Cl₂N₂O₆

There total 12 articles about C₂₇H₃₄Cl₂N₂O₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3'S,4'S)-6-[2-(2,6-dichloro-4-methyl-phenoxy)ethoxy]-3',4',5',6'-tetrahydro-2'H-[3,4']bipyridinyl-1',3'-dicarboxylic acid 1'-tert-butyl ester 3'-ethyl ester (1265907-55-8) → C27H34Cl2N2O6 (1265907-56-9)

Guidance literature:

With sodium ethanolate; In ethanol; at 70 ℃; for 1h; optical yield given as %de; Inert atmosphere;

DOI:10.1021/jo102070e

Reference yield:

2-[2-(2,6-dichloro-4-methyl-phenoxy)ethoxy]-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine (1206625-60-6) → C27H34Cl2N2O6 (1265907-56-9)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 1.08 h / 50 - 83 °C / Inert atmosphere; Large scale reaction

2: tetrafluoroboric acid diethyl ether; [bis(2-methylallyl)cycloocta-1,5-diene]ruthenium(II); Josiphos SL-J₂₁₂-1; hydrogen / tetrahydrofuran; dichloromethane / 20 h / 15 °C / 41372.9 Torr / Autoclave; Large scale reaction

3: sodium ethanolate / ethanol / 1 h / 70 °C / Inert atmosphere

With tetrafluoroboric acid diethyl ether; [bis(2-methylallyl)cycloocta-1,5-diene]ruthenium(II); tetrakis(triphenylphosphine) palladium⁽⁰⁾; Josiphos SL-J₂₁₂-1; hydrogen; sodium ethanolate; sodium carbonate; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water; 1: Suzuki coupling;

DOI:10.1021/jo102070e

Reference yield:

5-bromo-2-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]pyridine (945999-98-4) → C27H34Cl2N2O6 (1265907-56-9)

Guidance literature:

Multi-step reaction with 4 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / N,N-dimethyl acetamide / 20 h / 80 - 85 °C / Inert atmosphere; Large scale reaction

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 1.08 h / 50 - 83 °C / Inert atmosphere; Large scale reaction

3: tetrafluoroboric acid diethyl ether; [bis(2-methylallyl)cycloocta-1,5-diene]ruthenium(II); Josiphos SL-J₂₁₂-1; hydrogen / tetrahydrofuran; dichloromethane / 20 h / 15 °C / 41372.9 Torr / Autoclave; Large scale reaction

4: sodium ethanolate / ethanol / 1 h / 70 °C / Inert atmosphere

With tetrafluoroboric acid diethyl ether; [bis(2-methylallyl)cycloocta-1,5-diene]ruthenium(II); tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; Josiphos SL-J₂₁₂-1; hydrogen; sodium ethanolate; potassium acetate; sodium carbonate; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; N,N-dimethyl acetamide; water; 2: Suzuki coupling;

DOI:10.1021/jo102070e

upstream raw materials:

5-bromo-2-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]pyridine

6-[2-(2,6-dichloro-4-methyl-phenoxy)ethoxy]-5',6'-dihydro-2'H-[3,4']bipyridinyl-1',3'-dicarboxylic acid 1'-tert-butyl ester 3'-ethyl ester

6-[2-(2,6-dichloro-4-methyl-phenoxy)ethoxy]-1'-(2,2,2-trifluoroacetyl)-1',2',5',6'-tetrahydro-[3,4']bipyridinyl-3'-carboxylic acid ethyl ester

(3'S,4'S)-6-[2-(2,6-dichloro-4-methyl-phenoxy)ethoxy]-3',4',5',6'-tetrahydro-2'H-[3,4']bipyridinyl-1',3'-dicarboxylic acid 1'-tert-butyl ester 3'-ethyl ester