(3aR,6S,7aR)-3-((3R,4R)-5-Benzyloxymethoxy-3-hydroxy-4-methyl-pentanoyl)-3a,4,5,6,7,7a-hexahydro-benzo[d]isoxazole-6-carboxylic acid methyl ester

Base Information

Chemical Name:(3aR,6S,7aR)-3-((3R,4R)-5-Benzyloxymethoxy-3-hydroxy-4-methyl-pentanoyl)-3a,4,5,6,7,7a-hexahydro-benzo[d]isoxazole-6-carboxylic acid methyl ester
CAS No.:109667-82-5
Molecular Formula:C₂₃H₃₁NO₇
Molecular Weight:433.502
Hs Code.:

(3aR,6S,7aR)-3-((3R,4R)-5-Benzyloxymethoxy-3-hydroxy-4-methyl-pentanoyl)-3a,4,5,6,7,7a-hexahydro-benzo[d]isoxazole-6-carboxylic acid methyl ester

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Chemical Property of (3aR,6S,7aR)-3-((3R,4R)-5-Benzyloxymethoxy-3-hydroxy-4-methyl-pentanoyl)-3a,4,5,6,7,7a-hexahydro-benzo[d]isoxazole-6-carboxylic acid methyl ester

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Technology Process of (3aR,6S,7aR)-3-((3R,4R)-5-Benzyloxymethoxy-3-hydroxy-4-methyl-pentanoyl)-3a,4,5,6,7,7a-hexahydro-benzo[d]isoxazole-6-carboxylic acid methyl ester

There total 5 articles about (3aR,6S,7aR)-3-((3R,4R)-5-Benzyloxymethoxy-3-hydroxy-4-methyl-pentanoyl)-3a,4,5,6,7,7a-hexahydro-benzo[d]isoxazole-6-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109667-78-9
N-(4-chloro-7-oxo-6-oxabicyclo[3.2.1]octan-3-yl)acetamide

: 109667-82-5
(3aR,6S,7aR)-3-((3R,4R)-5-Benzyloxymethoxy-3-hydroxy-4-methyl-pentanoyl)-3a,4,5,6,7,7a-hexahydro-benzo[d]isoxazole-6-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 45 percent / toluene / 18 h / Heating

2: 85 percent / K₂CO₃ / 0.5 h / Ambient temperature

3: 83 percent / DMAP / CH₂Cl₂ / 26 h / Ambient temperature

4: 65 percent / Bu₃SnH / AIBN / benzene / 2 h / Heating

5: SnCl₄ / CH₂Cl₂ / -78 - -20 °C

With dmap; tri-n-butyl-tin hydride; tin(IV) chloride; potassium carbonate; 2,2'-azobis(isobutyronitrile); In dichloromethane; toluene; benzene;
DOI:10.1021/jo00392a046

Reference yield:

: 109586-31-4
methyl (1S,2R,4S,6R)-9-acetyl-2-hydroxy-7-oxa-8-azabicyclo<4.3.0>non-8-ene-4-carboxylate

: 109667-82-5
(3aR,6S,7aR)-3-((3R,4R)-5-Benzyloxymethoxy-3-hydroxy-4-methyl-pentanoyl)-3a,4,5,6,7,7a-hexahydro-benzo[d]isoxazole-6-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / DMAP / CH₂Cl₂ / 26 h / Ambient temperature

2: 65 percent / Bu₃SnH / AIBN / benzene / 2 h / Heating

3: SnCl₄ / CH₂Cl₂ / -78 - -20 °C

With dmap; tri-n-butyl-tin hydride; tin(IV) chloride; 2,2'-azobis(isobutyronitrile); In dichloromethane; benzene;
DOI:10.1021/jo00392a046

Reference yield:

: 119680-64-7
methyl (1S,2R,4S,6R)-9-acetyl-2-<(phenoxythionocarbonyl)oxy>-7-oxa-8-azabicyclo<4.3.0>non-8-ene-4-carboxylate

: 109667-82-5
(3aR,6S,7aR)-3-((3R,4R)-5-Benzyloxymethoxy-3-hydroxy-4-methyl-pentanoyl)-3a,4,5,6,7,7a-hexahydro-benzo[d]isoxazole-6-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / Bu₃SnH / AIBN / benzene / 2 h / Heating

2: SnCl₄ / CH₂Cl₂ / -78 - -20 °C

With tri-n-butyl-tin hydride; tin(IV) chloride; 2,2'-azobis(isobutyronitrile); In dichloromethane; benzene;
DOI:10.1021/jo00392a046