Lithium; (2S,4S)-1-{(S)-6-amino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-4-phenylsulfanyl-pyrrolidine-2-carboxylate

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Chemical Name:Lithium; (2S,4S)-1-{(S)-6-amino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-4-phenylsulfanyl-pyrrolidine-2-carboxylate
CAS No.:126187-75-5
Molecular Formula:C₂₇H₃₅N₂O₆PS*2Li
Molecular Weight:560.506
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Lithium; (2S,4S)-1-{(S)-6-amino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-4-phenylsulfanyl-pyrrolidine-2-carboxylate

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Technology Process of Lithium; (2S,4S)-1-{(S)-6-amino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-4-phenylsulfanyl-pyrrolidine-2-carboxylate

There total 18 articles about Lithium; (2S,4S)-1-{(S)-6-amino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-4-phenylsulfanyl-pyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 126110-83-6,126187-80-2
<1(R^*),2α,4β>-1-<2-<oxy>-1-oxo-6-<(trifluoroacetyl)amino>hexyl>-4-(phenylthio)-L-proline methyl ester

: 126187-75-5,126251-89-6
<1(R^*),2α,4β>-1-<6-amino-2-<oxy>-1-oxohexyl>-4-(phenylthio)-L-proline dilithium salt

Guidance literature:: With lithium hydroxide; In 1,4-dioxane; for 2h; Ambient temperature;
DOI:10.1021/jm00167a028

Reference yield: 80.0%

: 126110-83-6,126187-80-2
(2S,4S)-1-[(S)-2-[Hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-6-(2,2,2-trifluoro-acetylamino)-hexanoyl]-4-phenylsulfanyl-pyrrolidine-2-carboxylic acid methyl ester

: 126187-75-5,126251-89-6
Lithium; (2S,4S)-1-{(S)-6-amino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-4-phenylsulfanyl-pyrrolidine-2-carboxylate

Guidance literature:: With lithium hydroxide; In 1,4-dioxane; for 2h; Ambient temperature;
DOI:10.1021/jm00167a028

Reference yield:

: 42491-84-9
(S)-6-Amino-2-hydroxyhexanoic acid

: 126187-75-5,126251-89-6
<1(R^*),2α,4β>-1-<6-amino-2-<oxy>-1-oxohexyl>-4-(phenylthio)-L-proline dilithium salt

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) bis(trimethylsilyl)trifluoroacetamide / 1.) acetonitrile, room temp., 2 h

2: potassium carbonate / dimethylformamide / 5 h / Ambient temperature

3: N,N'-dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / tetrahydrofuran / 2 h / Ambient temperature

4: NaIO₄ / dioxane; H₂O / 18 h / Ambient temperature

5: H₂ / 10percent Pd/C / methanol; H₂O / 2 h / 1551.4 Torr

6: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / 0 °C

7: triethylamine / tetrahydrofuran / 4.5 h / Ambient temperature

8: 87 percent / 1.0 N LiOH / dioxane / 2 h / Ambient temperature

With dmap; lithium hydroxide; sodium periodate; bis(trimethylsilyl)trifluoroacetamide; hydrogen; potassium carbonate; triethylamine; dicyclohexyl-carbodiimide; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00167a028