2-(4-{5-amino-4-[2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-butyl)-benzo[de]isoquinoline-1,3-dione

Base Information

• Chemical Name: 2-(4-{5-amino-4-[2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-butyl)-benzo[de]isoquinoline-1,3-dione
• CAS No.: 482378-32-5
• Molecular Formula: C₃₃H₃₉N₃O₅S₂
• Molecular Weight: 621.822
• Mol file: 482378-32-5.mol

Synonyms:

Chemical Property of 2-(4-{5-amino-4-[2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-butyl)-benzo[de]isoquinoline-1,3-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-{5-amino-4-[2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-butyl)-benzo[de]isoquinoline-1,3-dione

There total 12 articles about 2-(4-{5-amino-4-[2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-butyl)-benzo[de]isoquinoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-{4-[2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-butyl)-benzo[de]isoquinoline-1,3-dione (482378-26-7) → 2-(4-{5-amino-4-[2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-butyl)-benzo[de]isoquinoline-1,3-dione (482378-32-5)

Guidance literature:

With tin(ll) chloride; In methanol;

DOI:10.1016/S0960-894X(02)00326-8

Reference yield:

1,8-Naphthalimide (81-83-4) → 2-(4-{5-amino-4-[2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-butyl)-benzo[de]isoquinoline-1,3-dione (482378-32-5)

Guidance literature:

Multi-step reaction with 3 steps

1: K₂CO₃ / acetone / Heating

2: K₂CO₃ / acetone / Heating

3: SnCl₂*2H₂O / methanol

With potassium carbonate; tin(ll) chloride; In methanol; acetone;

DOI:10.1016/S0960-894X(02)00326-8

Reference yield:

1,8-Naphthalic anhydride (81-84-5) → 2-(4-{5-amino-4-[2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-butyl)-benzo[de]isoquinoline-1,3-dione (482378-32-5)

Guidance literature:

Multi-step reaction with 4 steps

1: NH₃ (liquid) / Heating

2: K₂CO₃ / acetone / Heating

3: K₂CO₃ / acetone / Heating

4: SnCl₂*2H₂O / methanol

With ammonia; potassium carbonate; tin(ll) chloride; In methanol; acetone;

DOI:10.1016/S0960-894X(02)00326-8

upstream raw materials:

2-(4-{4-[2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-butyl)-benzo[de]isoquinoline-1,3-dione

1,8-Naphthalimide

1,8-Naphthalic anhydride

4-(benzyloxy)-5-methoxy-2-nitrobenzoic acid