tert-Butyl-(4R)-3-hydroxy-4-<(phenyloxycarbonyl)(3-methyl-2-butenyl)amino>-5-pentanoate

Base Information

Chemical Name:tert-Butyl-(4R)-3-hydroxy-4-<(phenyloxycarbonyl)(3-methyl-2-butenyl)amino>-5-pentanoate
CAS No.:131304-91-1
Molecular Formula:C₂₇H₄₅NO₆Si
Molecular Weight:507.743
Hs Code.:

tert-Butyl-(4R)-3-hydroxy-4-<(phenyloxycarbonyl)(3-methyl-2-butenyl)amino>-5-<tert-butyldimethylsilyl)oxy>pentanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-Butyl-(4R)-3-hydroxy-4-<(phenyloxycarbonyl)(3-methyl-2-butenyl)amino>-5-pentanoate

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Technology Process of tert-Butyl-(4R)-3-hydroxy-4-<(phenyloxycarbonyl)(3-methyl-2-butenyl)amino>-5-pentanoate

There total 5 articles about tert-Butyl-(4R)-3-hydroxy-4-<(phenyloxycarbonyl)(3-methyl-2-butenyl)amino>-5-pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98642-63-8
(R)-2-amino-3-((tert-butyldimethylsilyl)oxy)propionic acid methyl ester

: 131304-91-1,131304-92-2
tert-Butyl-(4R)-3-hydroxy-4-<(phenyloxycarbonyl)(3-methyl-2-butenyl)amino>-5-pentanoate

Guidance literature:: Multi-step reaction with 5 steps

1: benzene / 0.5 h / Ambient temperature

2: sodium borohydride / methanol / a.) 0 deg C, 0.2h, b.) 0 deg C to r.t., 0.3h

3: 92 percent / aq. sodium bicarbonate / ethyl acetate / 1 h / 0 °C

4: 4.36 g / diisobutylaluminium hydride (Dibal) / toluene / 1.85 h / -78 °C

5: 1. diisopropylamine, n-butyllithium / 1. THF, -78 deg C, 0.25h, 2. THF, -78 deg C, 0.25h

With sodium tetrahydroborate; n-butyllithium; diisobutylaluminium hydride; sodium hydrogencarbonate; diisopropylamine; In methanol; ethyl acetate; toluene; benzene;
DOI:10.1016/S0040-4020(01)87906-0

Reference yield:

: (R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[3-methyl-but-2-en-(Z)-ylideneamino]-propionic acid methyl ester

: 131304-91-1,131304-92-2
tert-Butyl-(4R)-3-hydroxy-4-<(phenyloxycarbonyl)(3-methyl-2-butenyl)amino>-5-pentanoate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium borohydride / methanol / a.) 0 deg C, 0.2h, b.) 0 deg C to r.t., 0.3h

2: 92 percent / aq. sodium bicarbonate / ethyl acetate / 1 h / 0 °C

3: 4.36 g / diisobutylaluminium hydride (Dibal) / toluene / 1.85 h / -78 °C

4: 1. diisopropylamine, n-butyllithium / 1. THF, -78 deg C, 0.25h, 2. THF, -78 deg C, 0.25h

With sodium tetrahydroborate; n-butyllithium; diisobutylaluminium hydride; sodium hydrogencarbonate; diisopropylamine; In methanol; ethyl acetate; toluene;
DOI:10.1016/S0040-4020(01)87906-0

Reference yield:

: 131304-90-0
Methyl-(2R)-<3-(tert-butyldimethylsilyl)oxy>-2-<(3-methyl-2-butenyl)amino> propionate

: 131304-91-1,131304-92-2
tert-Butyl-(4R)-3-hydroxy-4-<(phenyloxycarbonyl)(3-methyl-2-butenyl)amino>-5-pentanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / aq. sodium bicarbonate / ethyl acetate / 1 h / 0 °C

2: 4.36 g / diisobutylaluminium hydride (Dibal) / toluene / 1.85 h / -78 °C

3: 1. diisopropylamine, n-butyllithium / 1. THF, -78 deg C, 0.25h, 2. THF, -78 deg C, 0.25h

With n-butyllithium; diisobutylaluminium hydride; sodium hydrogencarbonate; diisopropylamine; In ethyl acetate; toluene;
DOI:10.1016/S0040-4020(01)87906-0