Technology Process of 7,8-dibenzyloxy-6-[4-(3,4-dibenzyloxy-5,6,8-trimethoxynaphthalen-2-yl)-1-hydroxy-3-oxobutyl]-1-oxo-1H-isochromene-3-carboxylic acid methyl ester
There total 8 articles about 7,8-dibenzyloxy-6-[4-(3,4-dibenzyloxy-5,6,8-trimethoxynaphthalen-2-yl)-1-hydroxy-3-oxobutyl]-1-oxo-1H-isochromene-3-carboxylic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sodium dithionite; water / benzene / 0.08 h
2.1: potassium carbonate / 6 h / Reflux
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C
4.1: Dess-Martin periodane / dichloromethane / 1 h
5.1: ammonium acetate / 0.5 h / Reflux
6.1: sodium tetrahydroborate / methanol; chloroform / 0.08 h
6.2: pH 3
7.1: phenyl isocyanate; triethylamine / benzene / 17 h / 65 - 70 °C
8.1: hydrogen; boric acid / tetrahydrofuran; methanol; water / 8 h
With
sodium tetrahydroborate; lithium aluminium tetrahydride; sodium dithionite; ammonium acetate; water; hydrogen; boric acid; potassium carbonate; Dess-Martin periodane; phenyl isocyanate; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane; chloroform; water; benzene;
DOI:10.1021/jo200399z
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: potassium carbonate / 6 h / Reflux
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C
3.1: Dess-Martin periodane / dichloromethane / 1 h
4.1: ammonium acetate / 0.5 h / Reflux
5.1: sodium tetrahydroborate / methanol; chloroform / 0.08 h
5.2: pH 3
6.1: phenyl isocyanate; triethylamine / benzene / 17 h / 65 - 70 °C
7.1: hydrogen; boric acid / tetrahydrofuran; methanol; water / 8 h
With
sodium tetrahydroborate; lithium aluminium tetrahydride; ammonium acetate; hydrogen; boric acid; potassium carbonate; Dess-Martin periodane; phenyl isocyanate; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane; chloroform; water; benzene;
DOI:10.1021/jo200399z
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: Dess-Martin periodane / dichloromethane / 1 h
2.1: ammonium acetate / 0.5 h / Reflux
3.1: sodium tetrahydroborate / methanol; chloroform / 0.08 h
3.2: pH 3
4.1: phenyl isocyanate; triethylamine / benzene / 17 h / 65 - 70 °C
5.1: hydrogen; boric acid / tetrahydrofuran; methanol; water / 8 h
With
sodium tetrahydroborate; ammonium acetate; hydrogen; boric acid; Dess-Martin periodane; phenyl isocyanate; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane; chloroform; water; benzene;
DOI:10.1021/jo200399z
