(1,3-Phenylene)bis[(pyridin-2-yl)methanone]

Base Information

Chemical Name:(1,3-Phenylene)bis[(pyridin-2-yl)methanone]
CAS No.:113786-97-3
Molecular Formula:C₁₈H₁₂N₂O₂
Molecular Weight:288.305
Hs Code.:
DSSTox Substance ID:DTXSID60514315
Nikkaji Number:J1.866.391K
Wikidata:Q82374565

Synonyms:113786-97-3;(1,3-Phenylene)bis[(pyridin-2-yl)methanone];DTXSID60514315

Suppliers and Price of (1,3-Phenylene)bis[(pyridin-2-yl)methanone]

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1,3-Phenylene)bis[(pyridin-2-yl)methanone]

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:288.089877630
Heavy Atom Count:22
Complexity:374

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=NC(=C1)C(=O)C2=CC(=CC=C2)C(=O)C3=CC=CC=N3

Technology Process of (1,3-Phenylene)bis[(pyridin-2-yl)methanone]

There total 5 articles about (1,3-Phenylene)bis[(pyridin-2-yl)methanone] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 17624-36-1
2-pyridyllithium

: 13698-87-8
N¹,N¹,N³,N³-tetraethylisophthalamide

: 113786-97-3
1,3-bis(2-pyridinecarbonyl)benzene

Guidance literature:: In diethyl ether; hexane; at -78 - 20 ℃;
DOI:10.1016/j.tet.2004.02.035

Reference yield:

: 113786-95-1
1,3-bis<1-(pyridin-2-yl)ethenyl>benzene

: 113786-97-3
1,3-bis(2-pyridinecarbonyl)benzene

Guidance literature:: With dimethylsulfide; ozone; Yield given. Multistep reaction; 1.) EtOAc, -50 deg C, 2.) EtOAc;

Reference yield:

: 109-04-6
2-bromo-pyridine

: 113786-97-3
1,3-bis(2-pyridinecarbonyl)benzene

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Ph-Br, Li / 1.) ether, 2.) ether, -50 deg C, 15 min, 3.) ether, -50 deg C, then room t., 2 h

2: 66 percent / glacial AcOH, conc. H₂SO₄ / 24 h

3: 1.) O₃, 2.) Me₂S / 1.) EtOAc, -50 deg C, 2.) EtOAc

With bromobenzene; dimethylsulfide; sulfuric acid; lithium; ozone; acetic acid;