(1S)(3-CHLOROPHENYL)CYCLOPROPYLMETHYLAMINE

Base Information

• Chemical Name: (1S)(3-CHLOROPHENYL)CYCLOPROPYLMETHYLAMINE
• CAS No.: 1075715-54-6
• Molecular Formula: C₁₀H₁₂ClN
• Molecular Weight: 181.665

Synonyms:

Chemical Property of (1S)(3-CHLOROPHENYL)CYCLOPROPYLMETHYLAMINE

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S)(3-CHLOROPHENYL)CYCLOPROPYLMETHYLAMINE

There total 2 articles about (1S)(3-CHLOROPHENYL)CYCLOPROPYLMETHYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C10H10ClN → C10H12ClN (1075715-54-6,1213903-33-3)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 20 ℃; for 0.25h;

DOI:10.1021/jacs.6b04660

Reference yield:

3-chloro-benzonitrile (766-84-7) → C10H12ClN (1075715-54-6,1213903-33-3)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 4 h / 70 °C

2: sodium tetrahydroborate / tetrahydrofuran; methanol / 0.25 h / 20 °C

With sodium tetrahydroborate; In tetrahydrofuran; methanol;

DOI:10.1021/jacs.6b04660

Reference yield:

C10H12ClN (1075715-54-6,1213903-33-3) → (S)-N-((3-chlorophenyl)(cyclopropyl)methyl)-4-nitrobenzenesulfonamide + (R)-N-((4-chloro-[1,1'-biphenyl]-2-yl)(cyclopropyl)methyl)-4-nitrobenzenesulfonamide

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: dimethyl sulfoxide; palladium diacetate; silver carbonate; (S)-tert-butyl (1-(methoxyamino)-1-oxo-3-phenylpropan-2-yl)carbamate; sodium carbonate; water / tert-Amyl alcohol / 15 h / 50 °C / Inert atmosphere; Sealed tube

With water; palladium diacetate; (S)-tert-butyl (1-(methoxyamino)-1-oxo-3-phenylpropan-2-yl)carbamate; sodium carbonate; dimethyl sulfoxide; triethylamine; silver carbonate; In tert-Amyl alcohol; dichloromethane;

DOI:10.1021/jacs.6b04660

upstream raw materials:

3-chloro-benzonitrile

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