4-fluoro-2-(4-fluorophenyl)-5-(6-methoxy-2-methyl-5-(1-(pyridin-2-yl)cyclopropylcarbamoyl)pyridin-3-yl)-N-methylpyrazolo[1,5-a]pyridine-3-carboxamide

Base Information

Chemical Name:4-fluoro-2-(4-fluorophenyl)-5-(6-methoxy-2-methyl-5-(1-(pyridin-2-yl)cyclopropylcarbamoyl)pyridin-3-yl)-N-methylpyrazolo[1,5-a]pyridine-3-carboxamide
CAS No.:1235741-42-0
Molecular Formula:C₃₁H₂₆F₂N₆O₃
Molecular Weight:568.583
Hs Code.:

4-fluoro-2-(4-fluorophenyl)-5-(6-methoxy-2-methyl-5-(1-(pyridin-2-yl)cyclopropylcarbamoyl)pyridin-3-yl)-N-methylpyrazolo[1,5-a]pyridine-3-carboxamide

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Chemical Property of 4-fluoro-2-(4-fluorophenyl)-5-(6-methoxy-2-methyl-5-(1-(pyridin-2-yl)cyclopropylcarbamoyl)pyridin-3-yl)-N-methylpyrazolo[1,5-a]pyridine-3-carboxamide

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Technology Process of 4-fluoro-2-(4-fluorophenyl)-5-(6-methoxy-2-methyl-5-(1-(pyridin-2-yl)cyclopropylcarbamoyl)pyridin-3-yl)-N-methylpyrazolo[1,5-a]pyridine-3-carboxamide

There total 7 articles about 4-fluoro-2-(4-fluorophenyl)-5-(6-methoxy-2-methyl-5-(1-(pyridin-2-yl)cyclopropylcarbamoyl)pyridin-3-yl)-N-methylpyrazolo[1,5-a]pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 38116-61-9
2-hydroxy-6-methylnicotinic acid

: 1235741-42-0
4-fluoro-2-(4-fluorophenyl)-5-(6-methoxy-2-methyl-5-(1-(pyridin-2-yl)cyclopropylcarbamoyl)pyridin-3-yl)-N-methylpyrazolo[1,5-a]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide; bromine; water / 0 - 20 °C

1.2: pH 1 - 2

2.1: silver carbonate / chloroform / 96 h / In the dark

3.1: 1,1'-bis-(diphenylphosphino)ferrocene / palladium diacetate / N,N-dimethyl-formamide / 3 h / 90 °C

4.1: trifluoroacetic acid / dichloromethane / 0.25 h / 20 °C

5.1: sodium hydroxide; water / 1,4-dioxane / 18 h / 20 °C

5.2: pH 4

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; water; bromine; N-ethyl-N,N-diisopropylamine; HATU; silver carbonate; trifluoroacetic acid; sodium hydroxide; palladium diacetate; In 1,4-dioxane; dichloromethane; chloroform; N,N-dimethyl-formamide;

Reference yield:

: 503437-35-2
5-bromo-2-hydroxy-6-methylnicotinic acid

: 1235741-42-0
4-fluoro-2-(4-fluorophenyl)-5-(6-methoxy-2-methyl-5-(1-(pyridin-2-yl)cyclopropylcarbamoyl)pyridin-3-yl)-N-methylpyrazolo[1,5-a]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: silver carbonate / chloroform / 96 h / In the dark

2.1: 1,1'-bis-(diphenylphosphino)ferrocene / palladium diacetate / N,N-dimethyl-formamide / 3 h / 90 °C

3.1: trifluoroacetic acid / dichloromethane / 0.25 h / 20 °C

4.1: sodium hydroxide; water / 1,4-dioxane / 18 h / 20 °C

4.2: pH 4

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; water; N-ethyl-N,N-diisopropylamine; HATU; silver carbonate; trifluoroacetic acid; sodium hydroxide; palladium diacetate; In 1,4-dioxane; dichloromethane; chloroform; N,N-dimethyl-formamide;

Reference yield:

: 1215106-58-3
tert-butyl 5-chloro-4-fluoro-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridine-3-carbonyl(methyl)carbamate

: 1235741-42-0
4-fluoro-2-(4-fluorophenyl)-5-(6-methoxy-2-methyl-5-(1-(pyridin-2-yl)cyclopropylcarbamoyl)pyridin-3-yl)-N-methylpyrazolo[1,5-a]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: bis(pinacol)diborane; potassium acetate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 3 h / 70 °C

2.1: 1,1'-bis-(diphenylphosphino)ferrocene / palladium diacetate / N,N-dimethyl-formamide / 3 h / 90 °C

3.1: trifluoroacetic acid / dichloromethane / 0.25 h / 20 °C

4.1: sodium hydroxide; water / 1,4-dioxane / 18 h / 20 °C

4.2: pH 4

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; water; potassium acetate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; bis(pinacol)diborane; sodium hydroxide; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium diacetate; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;