Methyl (methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-5-deoxy-3-S-phenyl-3-thio-β-D-erythro-L-gluco-2-nonulopyranosylonate)-(2->8)-(5-acetamido-4,7,9-tri-O-acetyl-5-deoxy-3-S-phenyl-3-thio-β-D-erythro-L-gluco-2-nonulopyranosyl)onate fluoride

Base Information

Chemical Name:Methyl (methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-5-deoxy-3-S-phenyl-3-thio-β-D-erythro-L-gluco-2-nonulopyranosylonate)-(2->8)-(5-acetamido-4,7,9-tri-O-acetyl-5-deoxy-3-S-phenyl-3-thio-β-D-erythro-L-gluco-2-nonulopyranosyl)onate fluoride
CAS No.:146815-49-8
Molecular Formula:C₅₀H₆₁FN₂O₂₃S₂
Molecular Weight:1141.16
Hs Code.:

Methyl (methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-5-deoxy-3-S-phenyl-3-thio-β-D-erythro-L-gluco-2-nonulopyranosylonate)-(2->8)-(5-acetamido-4,7,9-tri-O-acetyl-5-deoxy-3-S-phenyl-3-thio-β-D-erythro-L-gluco-2-nonulopyranosyl)onate fluoride

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Suppliers and Price of Methyl (methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-5-deoxy-3-S-phenyl-3-thio-β-D-erythro-L-gluco-2-nonulopyranosylonate)-(2->8)-(5-acetamido-4,7,9-tri-O-acetyl-5-deoxy-3-S-phenyl-3-thio-β-D-erythro-L-gluco-2-nonulopyranosyl)onate fluoride

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Chemical Property of Methyl (methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-5-deoxy-3-S-phenyl-3-thio-β-D-erythro-L-gluco-2-nonulopyranosylonate)-(2->8)-(5-acetamido-4,7,9-tri-O-acetyl-5-deoxy-3-S-phenyl-3-thio-β-D-erythro-L-gluco-2-nonulopyranosyl)onate fluoride

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Technology Process of Methyl (methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-5-deoxy-3-S-phenyl-3-thio-β-D-erythro-L-gluco-2-nonulopyranosylonate)-(2->8)-(5-acetamido-4,7,9-tri-O-acetyl-5-deoxy-3-S-phenyl-3-thio-β-D-erythro-L-gluco-2-nonulopyranosyl)onate fluoride

There total 9 articles about Methyl (methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-5-deoxy-3-S-phenyl-3-thio-β-D-erythro-L-gluco-2-nonulopyranosylonate)-(2->8)-(5-acetamido-4,7,9-tri-O-acetyl-5-deoxy-3-S-phenyl-3-thio-β-D-erythro-L-gluco-2-nonulopyranosyl)onate fluoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 120104-58-7
(2S,3S,4R,5S,6R)-4-Acetoxy-5-acetylamino-2-chloro-3-phenylsulfanyl-6-((1S,2R)-1,2,3-triacetoxy-propyl)-tetrahydro-pyran-2-carboxylic acid methyl ester

: 146815-49-8
Methyl (methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-5-deoxy-3-S-phenyl-3-thio-β-D-erythro-L-gluco-2-nonulopyranosylonate)-(2->8)-(5-acetamido-4,7,9-tri-O-acetyl-5-deoxy-3-S-phenyl-3-thio-β-D-erythro-L-gluco-2-nonulopyranosyl)onate fluoride

Guidance literature:: Multi-step reaction with 8 steps

1: AgOTf, aq. Na₂HPO₄ / acetonitrile / 1.) r.t., 30 min, 2.) 50 deg C, 22 h

2: DAST / CH₂Cl₂ / 1 h / -78 °C

3: 91 percent / t-BuOK / methanol / 3 h / Ambient temperature

4: 76 percent / Dowex 50Wx₈ (H(+)-form) / 6 h / Ambient temperature

5: 85 percent / pyridine / Ambient temperature

6: 76 percent / 80percent aq. AcOH / 8 h / 50 °C

7: 81 percent / pyridine / 5 h / -30 °C

8: 49 percent / AgOTf, Na₂HPO₄, 4 Angstroem molecular sieves / CH₂Cl₂; toluene / 1.) r.t., 30 h, 2.) 40 deg C, 20 h

With pyridine; disodium hydrogenphosphate; 4 A molecular sieve; Dowex 50Wx₈ (H(+)-form); potassium tert-butylate; silver trifluoromethanesulfonate; acetic acid; 4,4'-diaminostilbene-2,2'-disulfonic acid; In methanol; dichloromethane; toluene; acetonitrile;
DOI:10.1080/07328309608005696

Reference yield:

: 146815-48-7
(2R,3S,4R,5S,6R)-4-Acetoxy-6-[(S)-acetoxy-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-methyl]-5-acetylamino-2-fluoro-3-phenylsulfanyl-tetrahydro-pyran-2-carboxylic acid methyl ester

: 146815-49-8
Methyl (methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-5-deoxy-3-S-phenyl-3-thio-β-D-erythro-L-gluco-2-nonulopyranosylonate)-(2->8)-(5-acetamido-4,7,9-tri-O-acetyl-5-deoxy-3-S-phenyl-3-thio-β-D-erythro-L-gluco-2-nonulopyranosyl)onate fluoride

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / 80percent aq. AcOH / 8 h / 50 °C

2: 81 percent / pyridine / 5 h / -30 °C

3: 49 percent / AgOTf, Na₂HPO₄, 4 Angstroem molecular sieves / CH₂Cl₂; toluene / 1.) r.t., 30 h, 2.) 40 deg C, 20 h

With pyridine; disodium hydrogenphosphate; 4 A molecular sieve; silver trifluoromethanesulfonate; acetic acid; In dichloromethane; toluene;
DOI:10.1080/07328309608005696

Reference yield:

: 146815-46-5
(2R,3S,4R,5S,6R)-4-Acetoxy-5-acetylamino-2-fluoro-3-phenylsulfanyl-6-((1S,2R)-1,2,3-triacetoxy-propyl)-tetrahydro-pyran-2-carboxylic acid methyl ester

: 146815-49-8
Methyl (methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-5-deoxy-3-S-phenyl-3-thio-β-D-erythro-L-gluco-2-nonulopyranosylonate)-(2->8)-(5-acetamido-4,7,9-tri-O-acetyl-5-deoxy-3-S-phenyl-3-thio-β-D-erythro-L-gluco-2-nonulopyranosyl)onate fluoride

Guidance literature:: Multi-step reaction with 6 steps

1: 91 percent / t-BuOK / methanol / 3 h / Ambient temperature

2: 76 percent / Dowex 50Wx₈ (H(+)-form) / 6 h / Ambient temperature

3: 85 percent / pyridine / Ambient temperature

4: 76 percent / 80percent aq. AcOH / 8 h / 50 °C

5: 81 percent / pyridine / 5 h / -30 °C

6: 49 percent / AgOTf, Na₂HPO₄, 4 Angstroem molecular sieves / CH₂Cl₂; toluene / 1.) r.t., 30 h, 2.) 40 deg C, 20 h

With pyridine; disodium hydrogenphosphate; 4 A molecular sieve; Dowex 50Wx₈ (H(+)-form); potassium tert-butylate; silver trifluoromethanesulfonate; acetic acid; In methanol; dichloromethane; toluene;
DOI:10.1080/07328309608005696