2-[4-(4-{7-[2-(methanesulfonylmethylamino)phenyl]-5-methylpyrrolo[2,1-f][1,2,4]triazin-2-ylamino}-3-methoxy-phenyl)piperidin-1-yl]-acetamide

Base Information

Chemical Name:2-[4-(4-{7-[2-(methanesulfonylmethylamino)phenyl]-5-methylpyrrolo[2,1-f][1,2,4]triazin-2-ylamino}-3-methoxy-phenyl)piperidin-1-yl]-acetamide
CAS No.:1233180-64-7
Molecular Formula:C₂₉H₃₅N₇O₄S
Molecular Weight:577.707
Hs Code.:

2-[4-(4-{7-[2-(methanesulfonylmethylamino)phenyl]-5-methylpyrrolo[2,1-f][1,2,4]triazin-2-ylamino}-3-methoxy-phenyl)piperidin-1-yl]-acetamide

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Chemical Property of 2-[4-(4-{7-[2-(methanesulfonylmethylamino)phenyl]-5-methylpyrrolo[2,1-f][1,2,4]triazin-2-ylamino}-3-methoxy-phenyl)piperidin-1-yl]-acetamide

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Technology Process of 2-[4-(4-{7-[2-(methanesulfonylmethylamino)phenyl]-5-methylpyrrolo[2,1-f][1,2,4]triazin-2-ylamino}-3-methoxy-phenyl)piperidin-1-yl]-acetamide

There total 6 articles about 2-[4-(4-{7-[2-(methanesulfonylmethylamino)phenyl]-5-methylpyrrolo[2,1-f][1,2,4]triazin-2-ylamino}-3-methoxy-phenyl)piperidin-1-yl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1233180-67-0
C₁₅H₁₆N₄O₃S

: 1233180-64-7
2-[4-(4-{7-[2-(methanesulfonylmethylamino)phenyl]-5-methylpyrrolo[2,1-f][1,2,4]triazin-2-ylamino}-3-methoxy-phenyl)piperidin-1-yl]-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 0 °C

1.2: 20 °C

2.1: N,N-dimethyl-formamide / Heating

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jm2010767

Reference yield:

: 1116228-85-3
4-(3-methoxy-4-nitro-phenyl)-1,2,3,6-tetrahydropyridine

: 1233180-64-7
2-[4-(4-{7-[2-(methanesulfonylmethylamino)phenyl]-5-methylpyrrolo[2,1-f][1,2,4]triazin-2-ylamino}-3-methoxy-phenyl)piperidin-1-yl]-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / acetonitrile / 75 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 2.5 h / 2585.81 Torr

3: N,N-dimethyl-formamide / Heating

With palladium 10% on activated carbon; hydrogen; caesium carbonate; In methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm2010767

Reference yield:

: 1233181-97-9
2-[4-(3-methoxy-4-nitro-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-acetamide

: 1233180-64-7
2-[4-(4-{7-[2-(methanesulfonylmethylamino)phenyl]-5-methylpyrrolo[2,1-f][1,2,4]triazin-2-ylamino}-3-methoxy-phenyl)piperidin-1-yl]-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 2.5 h / 2585.81 Torr

2: N,N-dimethyl-formamide / Heating

With palladium 10% on activated carbon; hydrogen; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm2010767