3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-(2-hydroxyethyl) 5-methyl ester

Base Information

Chemical Name:3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-(2-hydroxyethyl) 5-methyl ester
CAS No.:113994-40-4
Molecular Formula:C20H25ClN2O6
Molecular Weight:424.881
Hs Code.:
Mol file:113994-40-4.mol

Synonyms:

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Chemical Property of 3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-(2-hydroxyethyl) 5-methyl ester

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Technology Process of 3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-(2-hydroxyethyl) 5-methyl ester

There total 3 articles about 3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-(2-hydroxyethyl) 5-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 120300-94-9
2-(2-azidoethoxy)methyl-4-(2-chlorophenyl)-3-(2-hydroxyethoxycarbonyl)-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine

: 113994-40-4
2-(2-aminoethoxy)methyl-4-(2-chlorophenyl)-3-(2-hydroxyethoxycarbonyl)-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine

Guidance literature:: With hydrogen; Lindlar's catalyst; In ethanol; Ambient temperature;
DOI:10.1016/0223-5234(91)90132-7

Reference yield:

: 103069-49-4
2-<(2-azidoethoxy)methyl>-4-(2-chlorophenyl)-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine

: 113994-40-4
2-(2-aminoethoxy)methyl-4-(2-chlorophenyl)-3-(2-hydroxyethoxycarbonyl)-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine

Guidance literature:: Multi-step reaction with 2 steps

1: carbodiimidazole / 1.) dichloromethane, 1 h, RT 2.) 100 deg C

2: 0.032 g / H₂ / Pd/CaCO₃ / ethanol / 1.5 h

With hydrogen; 1,1'-carbonyldiimidazole; Lindlar's catalyst; In ethanol;

Reference yield:

: 6-(2-Azido-ethoxymethyl)-4-(2-chloro-phenyl)-5-(imidazole-1-carbonyl)-2-methyl-1,4-dihydro-pyridine-3-carboxylic acid methyl ester

: 113994-40-4
2-(2-aminoethoxy)methyl-4-(2-chlorophenyl)-3-(2-hydroxyethoxycarbonyl)-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / Ambient temperature

2: 57 percent / H₂ / 5percent Pd/CaCO₃ / ethanol / Ambient temperature

With hydrogen; Lindlar's catalyst; In tetrahydrofuran; ethanol;
DOI:10.1016/0223-5234(91)90132-7