28-iodo-3',5'-dioxo-4'-phenyl-3β-(tert-butyldimethylsilyloxy)-5α,8α<1',2'>-1',2',4'-triazolidino-6-ergostene

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Chemical Name:28-iodo-3',5'-dioxo-4'-phenyl-3β-(tert-butyldimethylsilyloxy)-5α,8α<1',2'>-1',2',4'-triazolidino-6-ergostene
CAS No.:215022-89-2
Molecular Formula:C₄₂H₆₄IN₃O₃Si
Molecular Weight:813.978
Hs Code.:

Synonyms:

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Chemical Property of 28-iodo-3',5'-dioxo-4'-phenyl-3β-(tert-butyldimethylsilyloxy)-5α,8α<1',2'>-1',2',4'-triazolidino-6-ergostene

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Technology Process of 28-iodo-3',5'-dioxo-4'-phenyl-3β-(tert-butyldimethylsilyloxy)-5α,8α<1',2'>-1',2',4'-triazolidino-6-ergostene

There total 11 articles about 28-iodo-3',5'-dioxo-4'-phenyl-3β-(tert-butyldimethylsilyloxy)-5α,8α<1',2'>-1',2',4'-triazolidino-6-ergostene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18511-56-3
(3,3-dimethyloxiranyl)methanol

: 215022-89-2
28-iodo-3',5'-dioxo-4'-phenyl-3β-(tert-butyldimethylsilyloxy)-5α,8α<1',2'>-1',2',4'-triazolidino-6-ergostene

Guidance literature:: Multi-step reaction with 10 steps

1: 68 percent / n-BuLi / tetrahydrofuran; hexane / Ambient temperature

2: 86 percent / pyridine / 5 h / Ambient temperature

3: 77 percent / MeSO₂Cl, Et₃N / diethyl ether / a) 0 deg C, 5 h, b) RT, overnight

4: 75 percent / 20 percent KOH / ethanol / 1 h / Ambient temperature

5: 100 percent / H₂ / 5 percent Pd/C / methanol / 48 h / Ambient temperature

6: 75 percent / imidazole / dimethylformamide / 1 h / 55 °C

7: 1.) n-BuLi, 2.) 1,3-dimethyl-2-imidazolidinone / 1.) THF, hexane, -60 deg C, 30 min, 2.) THF, hexane, -20 deg C, 1 h

8: 5 percent Na/Hg, Na₂HPO₄ / tetrahydrofuran; methanol / Ambient temperature

9: pyridine / Ambient temperature

10: NaI / acetone / 3 h / Heating

With pyridine; 1H-imidazole; 1,3-dimethyl-2-imidazolidinone; potassium hydroxide; disodium hydrogenphosphate; sodium amalgam; n-butyllithium; hydrogen; methanesulfonyl chloride; triethylamine; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; N,N-dimethyl-formamide; acetone;
DOI:10.1248/cpb.46.1454

Reference yield:

: 556-82-1
3-methyl-2-buten-1-ol

: 215022-89-2
28-iodo-3',5'-dioxo-4'-phenyl-3β-(tert-butyldimethylsilyloxy)-5α,8α<1',2'>-1',2',4'-triazolidino-6-ergostene

Guidance literature:: Multi-step reaction with 11 steps

1: 65 percent / m-CPBA / CHCl₃ / Ambient temperature

2: 68 percent / n-BuLi / tetrahydrofuran; hexane / Ambient temperature

3: 86 percent / pyridine / 5 h / Ambient temperature

4: 77 percent / MeSO₂Cl, Et₃N / diethyl ether / a) 0 deg C, 5 h, b) RT, overnight

5: 75 percent / 20 percent KOH / ethanol / 1 h / Ambient temperature

6: 100 percent / H₂ / 5 percent Pd/C / methanol / 48 h / Ambient temperature

7: 75 percent / imidazole / dimethylformamide / 1 h / 55 °C

8: 1.) n-BuLi, 2.) 1,3-dimethyl-2-imidazolidinone / 1.) THF, hexane, -60 deg C, 30 min, 2.) THF, hexane, -20 deg C, 1 h

9: 5 percent Na/Hg, Na₂HPO₄ / tetrahydrofuran; methanol / Ambient temperature

10: pyridine / Ambient temperature

11: NaI / acetone / 3 h / Heating

With pyridine; 1H-imidazole; 1,3-dimethyl-2-imidazolidinone; potassium hydroxide; disodium hydrogenphosphate; sodium amalgam; n-butyllithium; hydrogen; methanesulfonyl chloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; chloroform; N,N-dimethyl-formamide; acetone;
DOI:10.1248/cpb.46.1454

Reference yield:

: 215022-85-8
3-methyl-2-(phenylsulfonylmethyl)-3-buten-1-ol

: 215022-89-2
28-iodo-3',5'-dioxo-4'-phenyl-3β-(tert-butyldimethylsilyloxy)-5α,8α<1',2'>-1',2',4'-triazolidino-6-ergostene

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / H₂ / 5 percent Pd/C / methanol / 48 h / Ambient temperature

2: 75 percent / imidazole / dimethylformamide / 1 h / 55 °C

3: 1.) n-BuLi, 2.) 1,3-dimethyl-2-imidazolidinone / 1.) THF, hexane, -60 deg C, 30 min, 2.) THF, hexane, -20 deg C, 1 h

4: 5 percent Na/Hg, Na₂HPO₄ / tetrahydrofuran; methanol / Ambient temperature

5: pyridine / Ambient temperature

6: NaI / acetone / 3 h / Heating

With pyridine; 1H-imidazole; 1,3-dimethyl-2-imidazolidinone; disodium hydrogenphosphate; sodium amalgam; n-butyllithium; hydrogen; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetone;
DOI:10.1248/cpb.46.1454