5-(2-Acetyl-3-hydroxy-4-propyl-2-thienyloxy)pentyl-p-toluensulfonsaeureester

Base Information

• Chemical Name: 5-(2-Acetyl-3-hydroxy-4-propyl-2-thienyloxy)pentyl-p-toluensulfonsaeureester
• CAS No.: 147068-08-4
• Molecular Formula: C₂₂H₃₀O₆S₂
• Molecular Weight: 454.609
• Mol file: 147068-08-4.mol

Synonyms:

Chemical Property of 5-(2-Acetyl-3-hydroxy-4-propyl-2-thienyloxy)pentyl-p-toluensulfonsaeureester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(2-Acetyl-3-hydroxy-4-propyl-2-thienyloxy)pentyl-p-toluensulfonsaeureester

There total 8 articles about 5-(2-Acetyl-3-hydroxy-4-propyl-2-thienyloxy)pentyl-p-toluensulfonsaeureester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

toluene-4-sulfonic acid (104-15-4) + 1-<5-(5-Hydroxypentyloxy)-3-methoxy-4-propyl-2-thienyl>ethanon (147068-07-3) → 5-(2-Acetyl-3-hydroxy-4-propyl-2-thienyloxy)pentyl-p-toluensulfonsaeureester (147068-08-4)

Guidance literature:

With pyridine; for 5h; Ambient temperature;

DOI:10.1002/ardp.19923251210

Reference yield:

1 ,5-pentanediol (111-29-5) → 5-(2-Acetyl-3-hydroxy-4-propyl-2-thienyloxy)pentyl-p-toluensulfonsaeureester (147068-08-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 1 h / 70 °C

2: 90 percent / K₂CO₃ / acetone / 4 h / Heating

3: 1) NaH / 1) toluene, 70 deg C, 1 h, 2) THF, r.t., 1 h

4: 94 percent / Al, HgCl₂ / tetrahydrofuran; H₂O / 1 h / 0 - 3 °C

5: 85 percent / pyridine / 5 h / Ambient temperature

With pyridine; sodium hydride; potassium carbonate; aluminium; mercury dichloride; In tetrahydrofuran; water; acetone;

DOI:10.1002/ardp.19923251210

Reference yield:

2-Dimethoxymethyl-pentanoic acid methyl ester → 5-(2-Acetyl-3-hydroxy-4-propyl-2-thienyloxy)pentyl-p-toluensulfonsaeureester (147068-08-4)

Guidance literature:

Multi-step reaction with 7 steps

1: 1) p-TsOH, 2) NaOMe / 1) 90 deg C, 2) MeOH, a) r.t., 1 h, b) reflux, 3 h

2: sulfuryl chloride / dioxane / 2 h / Ambient temperature

3: 1 h / 70 °C

4: 90 percent / K₂CO₃ / acetone / 4 h / Heating

5: 1) NaH / 1) toluene, 70 deg C, 1 h, 2) THF, r.t., 1 h

6: 94 percent / Al, HgCl₂ / tetrahydrofuran; H₂O / 1 h / 0 - 3 °C

7: 85 percent / pyridine / 5 h / Ambient temperature

With pyridine; sulfuryl dichloride; sodium methylate; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; aluminium; mercury dichloride; In tetrahydrofuran; 1,4-dioxane; water; acetone;

DOI:10.1002/ardp.19923251210

upstream raw materials:

toluene-4-sulfonic acid

1-<5-(5-Hydroxypentyloxy)-3-methoxy-4-propyl-2-thienyl>ethanon

1 ,5-pentanediol

3-Hydroxy-4-propylthiophen-2-carbonsaeuremethylester