butyl 3-(4-iodophenyl)-5-isobutylthiophen-2-ylsulphonylcarbamate

Base Information

• Chemical Name: butyl 3-(4-iodophenyl)-5-isobutylthiophen-2-ylsulphonylcarbamate
• CAS No.: 1256569-19-3
• Molecular Formula: C₁₉H₂₄INO₄S₂
• Molecular Weight: 521.44
• Mol file: 1256569-19-3.mol

Synonyms:

Chemical Property of butyl 3-(4-iodophenyl)-5-isobutylthiophen-2-ylsulphonylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of butyl 3-(4-iodophenyl)-5-isobutylthiophen-2-ylsulphonylcarbamate

There total 5 articles about butyl 3-(4-iodophenyl)-5-isobutylthiophen-2-ylsulphonylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(4-iodophenyl)-5-isobutylthiophene-2-sulphonamide (1256569-17-1) + carbonochloridic acid, butyl ester (592-34-7) → butyl 3-(4-iodophenyl)-5-isobutylthiophen-2-ylsulphonylcarbamate (1256569-19-3)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1002/jlcr.1793

Reference yield:

5-isobutyl-2 -(tert-butylaminosulfonyl)-3-thiopheneboronic acid (163520-14-7) → butyl 3-(4-iodophenyl)-5-isobutylthiophen-2-ylsulphonylcarbamate (1256569-19-3)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; ethanol; water / 0.17 h / 110 °C / Microwave irradiation

2: boron trichloride / dichloromethane / 1.17 h / 0 - 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 2 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron trichloride; sodium carbonate; triethylamine; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; 1: Suzuki coupling;

DOI:10.1002/jlcr.1793

Reference yield:

C18H34BNO4S2 → butyl 3-(4-iodophenyl)-5-isobutylthiophen-2-ylsulphonylcarbamate (1256569-19-3)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogenchloride / tetrahydrofuran; hexane; water / 0 °C / pH 2

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; ethanol; water / 0.17 h / 110 °C / Microwave irradiation

3: boron trichloride / dichloromethane / 1.17 h / 0 - 20 °C / Inert atmosphere

4: triethylamine / dichloromethane / 2 h / 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron trichloride; sodium carbonate; triethylamine; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; hexane; dichloromethane; water; 2: Suzuki coupling;

DOI:10.1002/jlcr.1793

upstream raw materials:

3-(4-iodophenyl)-5-isobutylthiophene-2-sulphonamide

carbonochloridic acid, butyl ester

N-(tert-butyl)-5-isobutylthiophene-2-sulphonamide

para-diiodobenzene

Downstream raw materials:

N-butoxycarbonyl-3-[4-(N-isopropyl-[⁽¹¹⁾C]-carbamoyl)phenyl]-5-isobutylthiophene-2-sulphonamide

N-butoxycarbonyl-3-[4-(N,N-diethyl-[⁽¹¹⁾C]-carbamoyl)phenyl]-5-isobutylthiophene-2-sulphonamide

N-butoxycarbonyl-3-[4-(N-benzyl-[⁽¹¹⁾C]-carbamoyl)phenyl]-5-isobutylthiophene-2-sulphonamide