Boc-Tyr-D-MetO-Phe-Sar-OCH₃

Base Information

• Chemical Name: Boc-Tyr-D-MetO-Phe-Sar-OCH₃
• CAS No.: 108269-57-4
• Molecular Formula: C₃₂H₄₄N₄O₉S
• Molecular Weight: 660.789
• Mol file: 108269-57-4.mol

Synonyms:

Chemical Property of Boc-Tyr-D-MetO-Phe-Sar-OCH₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Boc-Tyr-D-MetO-Phe-Sar-OCH₃

There total 3 articles about Boc-Tyr-D-MetO-Phe-Sar-OCH₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

Boc-Tyr-D-Met-Phe-Sar-OCH3 (108269-49-4) → Boc-Tyr-D-MetO-Phe-Sar-OCH3 (108269-57-4,108341-71-5)

Guidance literature:

With dihydrogen peroxide; In acetic acid; at 20 ℃; for 1h;

DOI:10.1021/jm00392a002

Reference yield:

Nα-Boc-Tyr-D-Met-Phe-OH (100572-39-2) → Boc-Tyr-D-MetO-Phe-Sar-OCH3 (108269-57-4,108341-71-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / dimethylformamide / a) 0 deg C, 2 h, b ) RT, 24 h

2: 89 percent / 11.2 M H₂O₂ / acetic acid / 1 h / 20 °C

With dihydrogen peroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In acetic acid; N,N-dimethyl-formamide;

DOI:10.1021/jm00392a002

Reference yield:

C33H45N3O8S → Boc-Tyr-D-MetO-Phe-Sar-OCH3 (108269-57-4,108341-71-5)

Guidance literature:

Multi-step reaction with 2 steps

1: N-methylmorpholine / dimethylformamide / a) -10 deg C, 1 h, b) from 0 deg C to 10 deg C, 3 h

2: 89 percent / 11.2 M H₂O₂ / acetic acid / 1 h / 20 °C

With 4-methyl-morpholine; dihydrogen peroxide; In acetic acid; N,N-dimethyl-formamide;

DOI:10.1021/jm00392a002

upstream raw materials:

Boc-Tyr-D-Met-Phe-Sar-OCH₃

N^α-Boc-Tyr-D-Met-Phe-OH