(R)-3-Benzylsulfanyl-2-[(R)-3-benzylsulfanyl-2-((S)-3-benzylsulfanyl-2-isobutyrylamino-2-methyl-propionylamino)-2-methyl-propionylamino]-2-methyl-propionic acid methyl ester

Base Information

Chemical Name:(R)-3-Benzylsulfanyl-2-[(R)-3-benzylsulfanyl-2-((S)-3-benzylsulfanyl-2-isobutyrylamino-2-methyl-propionylamino)-2-methyl-propionylamino]-2-methyl-propionic acid methyl ester
CAS No.:154960-17-5
Molecular Formula:C₃₈H₄₉N₃O₅S₃
Molecular Weight:724.022
Hs Code.:

(R)-3-Benzylsulfanyl-2-[(R)-3-benzylsulfanyl-2-((S)-3-benzylsulfanyl-2-isobutyrylamino-2-methyl-propionylamino)-2-methyl-propionylamino]-2-methyl-propionic acid methyl ester

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Chemical Property of (R)-3-Benzylsulfanyl-2-[(R)-3-benzylsulfanyl-2-((S)-3-benzylsulfanyl-2-isobutyrylamino-2-methyl-propionylamino)-2-methyl-propionylamino]-2-methyl-propionic acid methyl ester

Chemical Property:

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Technology Process of (R)-3-Benzylsulfanyl-2-[(R)-3-benzylsulfanyl-2-((S)-3-benzylsulfanyl-2-isobutyrylamino-2-methyl-propionylamino)-2-methyl-propionylamino]-2-methyl-propionic acid methyl ester

There total 12 articles about (R)-3-Benzylsulfanyl-2-[(R)-3-benzylsulfanyl-2-((S)-3-benzylsulfanyl-2-isobutyrylamino-2-methyl-propionylamino)-2-methyl-propionylamino]-2-methyl-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79-30-1
isobutyryl chloride

: (R)-2-[(R)-2-((S)-2-Amino-3-benzylsulfanyl-2-methyl-propionylamino)-3-benzylsulfanyl-2-methyl-propionylamino]-3-benzylsulfanyl-2-methyl-propionic acid methyl ester

: 154960-17-5
(R)-3-Benzylsulfanyl-2-[(R)-3-benzylsulfanyl-2-((S)-3-benzylsulfanyl-2-isobutyrylamino-2-methyl-propionylamino)-2-methyl-propionylamino]-2-methyl-propionic acid methyl ester

Guidance literature:: With triethylamine; Yield given;
DOI:10.1016/S0040-4039(00)76223-X

Reference yield:

: 15960-81-3
benzyl bromomethyl thioether

: 154960-17-5
(R)-3-Benzylsulfanyl-2-[(R)-3-benzylsulfanyl-2-((S)-3-benzylsulfanyl-2-isobutyrylamino-2-methyl-propionylamino)-2-methyl-propionylamino]-2-methyl-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 60 percent / LiNEt₂ / tetrahydrofuran; hexane / 1.) -78 deg C, 30 min, 2.) -78 deg C, 4 h, warm to 0 deg C

2: LiOH*H₂O / tetrahydrofuran; H₂O / 25 °C

3: DIEA, HOAt, CIP / CH₂Cl₂ / 24 h / 25 °C

4: HBr, AcOH / CH₂Cl₂ / 1 h / 25 °C

5: DIEA, HOAt, CIP / CH₂Cl₂ / 24 h / 25 °C

6: HBr, AcOH / CH₂Cl₂ / 1 h / 25 °C

7: Et₃N / CH₂Cl₂ / 2 h / 25 °C

With lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; lithium diethylamide; hydrogen bromide; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; dichloromethane; water;
DOI:10.1016/S0040-4020(97)00523-1

Reference yield:

: 155104-38-4
N^α-benzyloxycarbonyl-S-benzyl-(S)-methylcysteine

: 154960-17-5
(R)-3-Benzylsulfanyl-2-[(R)-3-benzylsulfanyl-2-((S)-3-benzylsulfanyl-2-isobutyrylamino-2-methyl-propionylamino)-2-methyl-propionylamino]-2-methyl-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: DIEA, HOAt, CIP / CH₂Cl₂ / 24 h / 25 °C

2: HBr, AcOH / CH₂Cl₂ / 1 h / 25 °C

3: Et₃N / CH₂Cl₂ / 2 h / 25 °C

With 1-hydroxy-7-aza-benzotriazole; hydrogen bromide; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/S0040-4020(97)00523-1