C₁₈H₁₇N₅O₃S

Base Information

Chemical Name:C₁₈H₁₇N₅O₃S
CAS No.:1226902-37-9
Molecular Formula:C₁₈H₁₇N₅O₃S
Molecular Weight:383.431
Hs Code.:

C<sub>18</sub>H<sub>17</sub>N<sub>5</sub>O<sub>3</sub>S

Synonyms:

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Chemical Property of C₁₈H₁₇N₅O₃S

Chemical Property:

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Technology Process of C₁₈H₁₇N₅O₃S

There total 8 articles about C₁₈H₁₇N₅O₃S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₂₅N₅O₅S

: 1226902-37-9
C₁₈H₁₇N₅O₃S

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; Reflux;
DOI:10.1021/jm4000215

Reference yield:

: 224185-19-7
3-bromo-4-fluoro-6-methylnitrobenzene

: 1226902-37-9
C₁₈H₁₇N₅O₃S

Guidance literature:: Multi-step reaction with 8 steps

1: sodium ethanolate / ethanol / 1 h / 20 °C

2: sodium dithionite; ethanol / water / 5 h / 100 °C

3: acetic acid; sodium nitrite / water / 20 °C

4: iodine; potassium hydroxide / N,N-dimethyl-formamide / 4 h / 20 °C

5: triethylamine / acetonitrile / 0.83 h / 20 °C

6: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / tetrahydrofuran; water / 6 h / Inert atmosphere; Reflux

7: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium carbonate / tetrahydrofuran; water / 5 h / Reflux

8: trifluoroacetic acid / dichloromethane / 20 °C / Reflux

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; sodium dithionite; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; ethanol; iodine; sodium ethanolate; palladium diacetate; sodium carbonate; potassium carbonate; acetic acid; triethylamine; trifluoroacetic acid; potassium hydroxide; sodium nitrite; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 6: |Suzuki Coupling / 7: |Suzuki Coupling;
DOI:10.1021/jm4000215

Reference yield:

: 1226903-38-3
1-bromo-2-ethoxy-4-methyl-5-nitrobenzene

: 1226902-37-9
C₁₈H₁₇N₅O₃S

Guidance literature:: Multi-step reaction with 7 steps

1: sodium dithionite; ethanol / water / 5 h / 100 °C

2: acetic acid; sodium nitrite / water / 20 °C

3: iodine; potassium hydroxide / N,N-dimethyl-formamide / 4 h / 20 °C

4: triethylamine / acetonitrile / 0.83 h / 20 °C

5: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / tetrahydrofuran; water / 6 h / Inert atmosphere; Reflux

6: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium carbonate / tetrahydrofuran; water / 5 h / Reflux

7: trifluoroacetic acid / dichloromethane / 20 °C / Reflux

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; sodium dithionite; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; ethanol; iodine; palladium diacetate; sodium carbonate; potassium carbonate; acetic acid; triethylamine; trifluoroacetic acid; potassium hydroxide; sodium nitrite; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 5: |Suzuki Coupling / 6: |Suzuki Coupling;
DOI:10.1021/jm4000215