1H-Pyrrole-1-carboxylic acid, 2,5-dihydro-2,5-dioxo-, 1,1-diMethylethyl ester

Base Information

• Chemical Name: 1H-Pyrrole-1-carboxylic acid, 2,5-dihydro-2,5-dioxo-, 1,1-diMethylethyl ester
• CAS No.: 114650-82-7
• Molecular Formula: C9H11NO4
• Molecular Weight: 197.191
• Mol file: 114650-82-7.mol

Synonyms:N-Boc-maleinimide;N-tert-butoxycarbonylmaleimide;

Chemical Property of 1H-Pyrrole-1-carboxylic acid, 2,5-dihydro-2,5-dioxo-, 1,1-diMethylethyl ester

Chemical Property:

• PSA: 63.68000
• LogP: 0.78440

Purity/Quality:

98%min ^*data from raw suppliers

tert-Butyl2,5-Dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrole-1-carboxylic acid, 2,5-dihydro-2,5-dioxo-, 1,1-diMethylethyl ester

There total 2 articles about 1H-Pyrrole-1-carboxylic acid, 2,5-dihydro-2,5-dioxo-, 1,1-diMethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

maleiimide (541-59-3,25721-74-8) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate (114650-82-7)

Guidance literature:

With dmap; In dichloromethane; at 20 ℃; for 0.166667h;

DOI:10.1021/acs.orglett.5b03021

Reference yield:

→ tert-butyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate (114650-82-7)

Guidance literature:

Reference yield: 100.0%

tert-butyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate (114650-82-7) + N-(4-(tert-butyl)phenyl)-2-((5,5-dimethyl-1,3,2-dioxaborinan-2-yl)methyl)acrylamide → C18H19NO3

Guidance literature:

With 18-crown-6 ether; ethanol; potassium carbonate; zinc dibromide; In chloroform; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1002/ejoc.201701112

upstream raw materials:

maleiimide

di-tert-butyl dicarbonate