Technology Process of 5α-(benzyloxymethyl)-1-ethenyl-5β,8aβ-dimethyl-trans-3,4,4a,5,6,7,8,8a-octahydronaphtalene
There total 4 articles about 5α-(benzyloxymethyl)-1-ethenyl-5β,8aβ-dimethyl-trans-3,4,4a,5,6,7,8,8a-octahydronaphtalene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) p-toluenesulphonylhydrazine, 2.) NaBH3CN / 1.) THF, reflux, 3 h, 2.) reflux, 8 h
2: 1.) NaH, 2.) H2O / 1.) THF, 4 h, reflux
3: tetrahydrofuran / 0.25 h / 0 °C
4: 1.) PBr3, 2.) LiBr, Li2CO3 / 1.) CH2Cl2, DMF, to 0 deg C, 3 h, 2.) 100 deg C, 3 h
With
water; phosphorus tribromide; lithium carbonate; sodium hydride; sodium cyanoborohydride; toluene-4-sulfonic acid hydrazide; lithium bromide;
In
tetrahydrofuran;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) NaH, 2.) H2O / 1.) THF, 4 h, reflux
2: tetrahydrofuran / 0.25 h / 0 °C
3: 1.) PBr3, 2.) LiBr, Li2CO3 / 1.) CH2Cl2, DMF, to 0 deg C, 3 h, 2.) 100 deg C, 3 h
With
water; phosphorus tribromide; lithium carbonate; sodium hydride; lithium bromide;
In
tetrahydrofuran;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: tetrahydrofuran / 0.25 h / 0 °C
2: 1.) PBr3, 2.) LiBr, Li2CO3 / 1.) CH2Cl2, DMF, to 0 deg C, 3 h, 2.) 100 deg C, 3 h
With
phosphorus tribromide; lithium carbonate; lithium bromide;
In
tetrahydrofuran;
![(4a'R,5'R,8a'S)-5'-(hydroxymethyl)-5',8a'-dimethylhexahydro-2'H-spiro[[1,3]dioxolane-2,1'-naphthalen]-6'(7'H)-one](/Databaselist/images/loading.webp)
