3-(3-(4-azidobutyl)-4-oxo-3,4-dihydroquinazolin-2-yl)-5-hydroxyphenyl acetate

Base Information

• Chemical Name: 3-(3-(4-azidobutyl)-4-oxo-3,4-dihydroquinazolin-2-yl)-5-hydroxyphenyl acetate
• CAS No.: 1427579-23-4
• Molecular Formula: C₂₀H₁₉N₅O₄
• Molecular Weight: 393.402
• Mol file: 1427579-23-4.mol

Synonyms:

Chemical Property of 3-(3-(4-azidobutyl)-4-oxo-3,4-dihydroquinazolin-2-yl)-5-hydroxyphenyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(3-(4-azidobutyl)-4-oxo-3,4-dihydroquinazolin-2-yl)-5-hydroxyphenyl acetate

There total 5 articles about 3-(3-(4-azidobutyl)-4-oxo-3,4-dihydroquinazolin-2-yl)-5-hydroxyphenyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C22H21ClN2O5 → 3-(4-azidobutyl)-2-(3,5-dihydroxyphenyl)quinazolin-4(3H)-one (1427579-17-6) + 3-(3-(4-azidobutyl)-4-oxo-3,4-dihydroquinazolin-2-yl)-5-hydroxyphenyl acetate (1427579-23-4)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 60 ℃;

DOI:10.1021/jm301757v

Reference yield:

2-(3,5-dihydroxyphenyl)quinazolin-4(3H)-one (1427578-65-1) → 3-(3-(4-azidobutyl)-4-oxo-3,4-dihydroquinazolin-2-yl)-5-hydroxyphenyl acetate (1427579-23-4)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 2 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

3: sodium azide / N,N-dimethyl-formamide / 60 °C

With pyridine; sodium azide; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm301757v

Reference yield:

anthranilic acid amide (28144-70-9,88-68-6) → 3-(3-(4-azidobutyl)-4-oxo-3,4-dihydroquinazolin-2-yl)-5-hydroxyphenyl acetate (1427579-23-4)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydrogen sulfate / N,N-dimethyl acetamide / 12 h / 145 °C

2: pyridine / dichloromethane / 2 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

4: sodium azide / N,N-dimethyl-formamide / 60 °C

With pyridine; sodium hydrogen sulfate; sodium azide; potassium carbonate; In dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;

DOI:10.1021/jm301757v

upstream raw materials:

2-(3,5-dihydroxyphenyl)quinazolin-4(3H)-one

anthranilic acid amide

5-(4-oxo-3,4-dihydroquinazolin-2-yl)-1,3-phenylene diacetate

3,5-dihydroxybenzaldehyde

Downstream raw materials:

C₃₇H₃₁N₇O₇

C₃₉H₃₃N₅O₁₁