(2S,1′R)-2-fluorocinacalcet hydrochloride

Base Information

Chemical Name:(2S,1′R)-2-fluorocinacalcet hydrochloride
CAS No.:1402230-83-4
Molecular Formula:C₂₂H₂₁F₄N*ClH
Molecular Weight:411.87
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,1′R)-2-fluorocinacalcet hydrochloride

Chemical Property:

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Technology Process of (2S,1′R)-2-fluorocinacalcet hydrochloride

There total 4 articles about (2S,1′R)-2-fluorocinacalcet hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1402230-86-7
C₁₀H₈F₄O

: 1402230-83-4
(2S,1′R)-2-fluorocinacalcet hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / 17 h / -15 °C

2: triethylamine; dmap / dichloromethane / 18 h / 0 - 20 °C

3: toluene / 16 h / Reflux

4: hydrogenchloride / diethyl ether

With hydrogenchloride; dmap; lithium aluminium tetrahydride; triethylamine; In diethyl ether; dichloromethane; toluene;
DOI:10.1039/c2ob26402a

Reference yield:

: 1402392-52-2
C₂₂H₂₁F₄N

: 1402230-83-4
(2S,1′R)-2-fluorocinacalcet hydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether;
DOI:10.1039/c2ob26402a

Reference yield:

: 21172-41-8
3-[3-(trifluoromethyl)phenyl]propanal

: 1402230-83-4
(2S,1′R)-2-fluorocinacalcet hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: N-fluorobis(benzenesulfon)imide; (S)-5-benzyl-2,2,3,-trimethylimidazolidin-4-one dichloroacetic acid salt / tetrahydrofuran; isopropyl alcohol / -15 °C

2: lithium aluminium tetrahydride / 17 h / -15 °C

3: triethylamine; dmap / dichloromethane / 18 h / 0 - 20 °C

4: toluene / 16 h / Reflux

5: hydrogenchloride / diethyl ether

With hydrogenchloride; dmap; lithium aluminium tetrahydride; (S)-5-benzyl-2,2,3,-trimethylimidazolidin-4-one dichloroacetic acid salt; N-fluorobis(benzenesulfon)imide; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; isopropyl alcohol; toluene;
DOI:10.1039/c2ob26402a