Technology Process of (+/-)-6-benzyl-6-methoxy-1,4-dimethylpiperazine-2,3,5-trione
There total 7 articles about (+/-)-6-benzyl-6-methoxy-1,4-dimethylpiperazine-2,3,5-trione which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 76 percent / triethylamine, H2 / 10percent palladized charcoal / ethyl acetate
2: 69 percent / CH2Cl2 / Ambient temperature
3: 68 percent / N-bromosuccinimide / 1 h / Ambient temperature
4: triethylamine, anhydrous potassium carbonate, H2 / 10percent palladized charcoal / ethyl acetate
5: 1.) ozone, 2.) dimethyl sulfide / 1.) dichloromethane, methanol, -78 deg C, 0.5 h, 2.) dichloromethane, methanol, RT
With
N-Bromosuccinimide; dimethylsulfide; hydrogen; potassium carbonate; ozone; triethylamine;
palladium on activated charcoal;
In
dichloromethane; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 69 percent / CH2Cl2 / Ambient temperature
2: 68 percent / N-bromosuccinimide / 1 h / Ambient temperature
3: triethylamine, anhydrous potassium carbonate, H2 / 10percent palladized charcoal / ethyl acetate
4: 1.) ozone, 2.) dimethyl sulfide / 1.) dichloromethane, methanol, -78 deg C, 0.5 h, 2.) dichloromethane, methanol, RT
With
N-Bromosuccinimide; dimethylsulfide; hydrogen; potassium carbonate; ozone; triethylamine;
palladium on activated charcoal;
In
dichloromethane; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 73 percent / p-toluenesulfonic acid / toluene / 18 h / Heating
2: 76 percent / triethylamine, H2 / 10percent palladized charcoal / ethyl acetate
3: 69 percent / CH2Cl2 / Ambient temperature
4: 68 percent / N-bromosuccinimide / 1 h / Ambient temperature
5: triethylamine, anhydrous potassium carbonate, H2 / 10percent palladized charcoal / ethyl acetate
6: 1.) ozone, 2.) dimethyl sulfide / 1.) dichloromethane, methanol, -78 deg C, 0.5 h, 2.) dichloromethane, methanol, RT
With
N-Bromosuccinimide; dimethylsulfide; hydrogen; potassium carbonate; toluene-4-sulfonic acid; ozone; triethylamine;
palladium on activated charcoal;
In
dichloromethane; ethyl acetate; toluene;
