endo-(4S)-2-oxo-4-isopropyl-4-phenyl-1,3,2-dioxathiolane

Base Information

• Chemical Name: endo-(4S)-2-oxo-4-isopropyl-4-phenyl-1,3,2-dioxathiolane
• CAS No.: 281223-05-0
• Molecular Formula: C₁₁H₁₄O₃S
• Molecular Weight: 226.296
• Mol file: 281223-05-0.mol

Synonyms:

Chemical Property of endo-(4S)-2-oxo-4-isopropyl-4-phenyl-1,3,2-dioxathiolane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of endo-(4S)-2-oxo-4-isopropyl-4-phenyl-1,3,2-dioxathiolane

There total 1 articles about endo-(4S)-2-oxo-4-isopropyl-4-phenyl-1,3,2-dioxathiolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-(-)-3-methyl-2-phenylbutane-1,2-diol (51559-18-3) → endo-(4S)-2-oxo-4-isopropyl-4-phenyl-1,3,2-dioxathiolane (281223-05-0) + exo-(4S)-2-oxo-4-isopropyl-4-phenyl-1,3,2-dioxathiolane (281223-06-1)

Guidance literature:

With thionyl chloride; triethylamine; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1016/S0040-4039(00)00315-4

Reference yield:

trimethylaluminum (75-24-1) + endo-(4S)-2-oxo-4-isopropyl-4-phenyl-1,3,2-dioxathiolane (281223-05-0) → (R)-2,3-Dimethyl-2-phenyl-butyric acid + (S)-2,3-Dimethyl-2-phenyl-butyric acid

Guidance literature:

trimethylaluminum; endo-(4S)-2-oxo-4-isopropyl-4-phenyl-1,3,2-dioxathiolane; In hexane; at -20 ℃; for 1h;

With chromium(VI) oxide; sulfuric acid; In acetone; at 20 ℃; for 0.25h; Title compound not separated from byproducts;

DOI:10.1016/S0040-4039(00)00315-4

Reference yield:

trimethylaluminum (75-24-1) + endo-(4S)-2-oxo-4-isopropyl-4-phenyl-1,3,2-dioxathiolane (281223-05-0) → (R)-2,3-dimethyl-2-phenylbutan-1-ol + (S)-2,3-Dimethyl-2-phenyl-butan-1-ol

Guidance literature:

In hexane; at -20 ℃; for 1h; Title compound not separated from byproducts;

DOI:10.1016/S0040-4039(00)00315-4

upstream raw materials:

(S)-(-)-3-methyl-2-phenylbutane-1,2-diol

Refernces