1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-3-(7-methoxy-6,7-dihydro-5H-pyrrolizin-1-ylmethyl)-5-methyl-1H-pyrimidine-2,4-dione

Base Information

• Chemical Name: 1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-3-(7-methoxy-6,7-dihydro-5H-pyrrolizin-1-ylmethyl)-5-methyl-1H-pyrimidine-2,4-dione
• CAS No.: 133787-49-2
• Molecular Formula: C₁₉H₂₅N₃O₆
• Molecular Weight: 391.424
• Mol file: 133787-49-2.mol

Synonyms:

Chemical Property of 1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-3-(7-methoxy-6,7-dihydro-5H-pyrrolizin-1-ylmethyl)-5-methyl-1H-pyrimidine-2,4-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-3-(7-methoxy-6,7-dihydro-5H-pyrrolizin-1-ylmethyl)-5-methyl-1H-pyrimidine-2,4-dione

There total 2 articles about 1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-3-(7-methoxy-6,7-dihydro-5H-pyrrolizin-1-ylmethyl)-5-methyl-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

thymidine (50-89-5,28854-96-8,3545-96-8,50-88-4) → Monocrotalic acid (26543-09-9) + monocrotaline pyrrole (23291-96-5) + 1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-3-(7-methoxy-6,7-dihydro-5H-pyrrolizin-1-ylmethyl)-5-methyl-1H-pyrimidine-2,4-dione (133787-49-2) + 1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-3-(7-hydroxymethyl-2,3-dihydro-1H-pyrrolizin-1-ylmethyl)-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:

With sodium hydrogencarbonate; In methanol; at 25 ℃; for 5h; Yields of byproduct given;

DOI:10.1016/S0040-4039(00)92122-1

Reference yield: 80.0%

monocrotaline pyrrole (23291-96-5) + thymidine (50-89-5,28854-96-8,3545-96-8,50-88-4) → Monocrotalic acid (26543-09-9) + dehydroretronecine dimethyl ether (28333-17-7) + 1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-3-(7-methoxy-6,7-dihydro-5H-pyrrolizin-1-ylmethyl)-5-methyl-1H-pyrimidine-2,4-dione (133787-49-2) + 1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-3-(7-hydroxymethyl-2,3-dihydro-1H-pyrrolizin-1-ylmethyl)-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:

With sodium hydrogencarbonate; In methanol; at 25 ℃; for 5h; Yields of byproduct given;

DOI:10.1016/S0040-4039(00)92122-1

upstream raw materials:

monocrotaline pyrrole

thymidine