H-Phe-Ser-Pro-Phe-Arg(NO₂)-OBzl

Base Information

Chemical Name:H-Phe-Ser-Pro-Phe-Arg(NO₂)-OBzl
CAS No.:2531-47-7
Molecular Formula:C₃₉H₄₉N₉O₉
Molecular Weight:787.873
Hs Code.:

H-Phe-Ser-Pro-Phe-Arg(NO<sub>2</sub>)-OBzl

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of H-Phe-Ser-Pro-Phe-Arg(NO₂)-OBzl

Chemical Property:

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Technology Process of H-Phe-Ser-Pro-Phe-Arg(NO₂)-OBzl

There total 11 articles about H-Phe-Ser-Pro-Phe-Arg(NO₂)-OBzl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 2531-47-7
H-Phe-Ser-Pro-Phe-Arg(NO₂)-OBzl

Guidance literature:: Multi-step reaction with 3 steps

1: 1) NMM, ethyl chloroformate, 2) NMM / 1) THF, 2) DMF, r.t.

2: 54 percent / 80percent hydrazine hydrate / Ambient temperature

3: 1) azide, 2) HCl, dioxane

With 1,4-dioxane; 4-methyl-morpholine; hydrogenchloride; chloroformic acid ethyl ester; hydrazine hydrate;
DOI:10.1246/bcsj.64.1533

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 2531-47-7
H-Phe-Ser-Pro-Phe-Arg(NO₂)-OBzl

Guidance literature:: Multi-step reaction with 6 steps

1: 1) N-methylmoprholine, ethyl chloroformate, 2) N-methylmorpholine / 1) THF, 2) DMF, r.t.

2: HCl, anisole / dioxane; tetrahydrofuran / 1 h

3: DCC, NMM, HOBt / dimethylformamide

4: TFA, anisole

5: DCC, NMM, HOBt / dimethylformamide / ice bath, 1 h, r.t., 41 h

6: TFA, anisole

With 4-methyl-morpholine; hydrogenchloride; chloroformic acid ethyl ester; benzotriazol-1-ol; methoxybenzene; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.64.1533

Reference yield:

: 55909-20-1
H-Phe-Arg(NO₂)-OBzl

: 2531-47-7
H-Phe-Ser-Pro-Phe-Arg(NO₂)-OBzl

Guidance literature:: Multi-step reaction with 6 steps

1: 1) N-methylmoprholine, ethyl chloroformate, 2) N-methylmorpholine / 1) THF, 2) DMF, r.t.

2: HCl, anisole / dioxane; tetrahydrofuran / 1 h

3: DCC, NMM, HOBt / dimethylformamide

4: TFA, anisole

5: DCC, NMM, HOBt / dimethylformamide / ice bath, 1 h, r.t., 41 h

6: TFA, anisole

With 4-methyl-morpholine; hydrogenchloride; chloroformic acid ethyl ester; benzotriazol-1-ol; methoxybenzene; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.64.1533